PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of postmedjPostgraduate Medical JournalVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Postgrad Med J. 1994 May; 70(823): 350–354.
PMCID: PMC2397596

Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastro-oesophageal reflux: a placebo-controlled cross-over study.

Abstract

Eleven adult patients with nocturnal asthma, and gastro-oesophageal reflux documented by endoscopy or ambulatory oesophageal pH monitoring completed a double-blind cross-over study (4 week treatment, one week run-in and cross-over periods) comparing the effects of omeprazole 20 mg daily and placebo on asthma control assessed by symptoms, peak expiratory flow rate and bronchodilator usage. Omeprazole treatment did not improve asthma symptoms during the day or night, or peak expiratory flow rate readings. There was no difference in bronchodilator inhaler usage during omeprazole therapy. Treatment of gastro-oesophageal reflux with omeprazole in patients with nocturnal asthma and gastro-oesophageal reflux does not improve asthma symptoms or peak expiratory flow rate. This suggests that gastro-oesophageal reflux does not exacerbate bronchoconstriction in nocturnal asthma.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (693K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Gastric asthma? Lancet. 1985 Dec 21;2(8469-70):1399–1400. [PubMed]
  • Tuchman DN, Boyle JT, Pack AI, Scwartz J, Kokonos M, Spitzer AR, Cohen S. Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology. 1984 Oct;87(4):872–881. [PubMed]
  • Harper PC, Bergner A, Kaye MD. Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux. Arch Intern Med. 1987 Jan;147(1):56–60. [PubMed]
  • MacDonald JB. Nocturnal asthma. BMJ. 1992 Apr 18;304(6833):998–999. [PMC free article] [PubMed]
  • Ekström T, Tibbling L. Gastro-oesophageal reflux and nocturnal asthma. Eur Respir J. 1988 Jul;1(7):636–638. [PubMed]
  • Ekström T, Tibbling L. Gastro-oesophageal reflux and triggering of bronchial asthma: a negative report. Eur J Respir Dis. 1987 Sep;71(3):177–180. [PubMed]
  • Mansfield LE. Gastroesophageal reflux and respiratory disorders: a review. Ann Allergy. 1989 Mar;62(3):158–163. [PubMed]
  • Sontag SJ, Schnell TG, Miller TQ, Khandelwal S, O'Connell S, Chejfec G, Greenlee H, Seidel UJ, Brand L. Prevalence of oesophagitis in asthmatics. Gut. 1992 Jul;33(7):872–876. [PMC free article] [PubMed]
  • Sontag SJ, O'Connell S, Khandelwal S, Miller T, Nemchausky B, Schnell TG, Serlovsky R. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology. 1990 Sep;99(3):613–620. [PubMed]
  • Mansfield LE, Stein MR. Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy. 1978 Oct;41(4):224–226. [PubMed]
  • Morrison JF, Pearson SB, Dean HG. Parasympathetic nervous system in nocturnal asthma. Br Med J (Clin Res Ed) 1988 May 21;296(6634):1427–1429. [PMC free article] [PubMed]
  • Pellegrini CA, DeMeester TR, Johnson LF, Skinner DB. Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. Surgery. 1979 Jul;86(1):110–119. [PubMed]
  • Kjellén G, Tibbling L, Wranne B. Effect of conservative treatment of oesophageal dysfunction on bronchial asthma. Eur J Respir Dis. 1981 Jun;62(3):190–197. [PubMed]
  • Goodall RJ, Earis JE, Cooper DN, Bernstein A, Temple JG. Relationship between asthma and gastro-oesophageal reflux. Thorax. 1981 Feb;36(2):116–121. [PMC free article] [PubMed]
  • Ekström T, Lindgren BR, Tibbling L. Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study. Thorax. 1989 Jan;44(1):19–23. [PMC free article] [PubMed]
  • Nagel RA, Brown P, Perks WH, Wilson RS, Kerr GD. Ambulatory pH monitoring of gastro-oesophageal reflux in "morning dipper" asthmatics. BMJ. 1988 Nov 26;297(6660):1371–1373. [PMC free article] [PubMed]
  • McTavish D, Buckley MM, Heel RC. Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders. Drugs. 1991 Jul;42(1):138–170. [PubMed]
  • Depla AC, Bartelsman JF, Roos CM, Tytgat GN, Jansen HM. Beneficial effect of omeprazole in a patient with severe bronchial asthma and gastro-oesophageal reflux. Eur Respir J. 1988 Dec;1(10):966–968. [PubMed]
  • DeMeester TR, Wang CI, Wernly JA, Pellegrini CA, Little AG, Klementschitsch P, Bermudez G, Johnson LF, Skinner DB. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg. 1980 May;79(5):656–670. [PubMed]
  • Hills M, Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol. 1979 Jul;8(1):7–20. [PubMed]
  • Kenward MG, Jones B. The analysis of data from 2 x 2 cross-over trials with baseline measurements. Stat Med. 1987 Dec;6(8):911–926. [PubMed]
  • Robinson M, Maton PN, Allen ML, Humphries TJ, McIntosh D, Cagliola AJ, Bradstreet TE. Effect of different doses of omeprazole on 24-hour oesophageal acid exposure in patients with gastro-oesophageal reflux. Aliment Pharmacol Ther. 1991 Dec;5(6):645–651. [PubMed]
  • Klinkenberg-Knol EC, Festen HP, Meuwissen SG. The effects of omeprazole and ranitidine on 24-hour pH in the distal oesophagus of patients with reflux oesophagitis. Aliment Pharmacol Ther. 1988 Jun;2(3):221–227. [PubMed]
  • Andersen LI, Schmidt A, Bundgaard A. Pulmonary function and acid application in the esophagus. Chest. 1986 Sep;90(3):358–363. [PubMed]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Group