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Br J Cancer. 2001 February; 84(3): 400–405.
PMCID: PMC2363747

Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989

Abstract

Since different histological types (HT) of gastric cancer (GC) may differ in their aetiology, time trend analysis by HT may afford an insight into aetiology. From the Gastric Cancer Registry of Japan, 161 067 cases diagnosed were retrieved between 1975 and 1989 to calculate the annual relative frequencies, stratified by age group and sex, of HT according to the Lauren and the Japanese Research Society for Gastric Cancer (JRSGC) classifications. Age- and sex-specific incidence rates by HT were estimated by multiplying the corresponding national cancer incidence rates of GC by the relative frequencies. Logistic regression models stratified by sex and age group were fitted to determine the time trends of HT. Using the Lauren classification, a decreasing trend of the intestinal type and a stable trend of the diffuse type were found. By the JRSGC classification, significant decreasing trends for most age groups were found for papillary and mucinous adenocarcinomas. Tubular adenocarcinomas (well differentiated type) showed a decreasing trend only in younger age groups. Tubular (moderately differentiated type), poorly differentiated adenocarcinomas, and signet ring cell carcinoma were statistically stable during the period. Considering changes in lifestyles of the Japanese, the result suggests that there are three aetiological types of GC. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: gastric cancer, histological type, time trend, epidemiology

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Selected References

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  • Amorosi A, Bianchi S, Buiatti E, Cipriani F, Palli D, Zampi G. Gastric cancer in a high-risk area in Italy. Histopathologic patterns according to Lauren's classification. Cancer. 1988 Nov 15;62(10):2191–2196. [PubMed]
  • Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, Miki K, Graham DY. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992 Mar;102(3):760–766. [PubMed]
  • Asaka M, Kimura T, Kato M, Kudo M, Miki K, Ogoshi K, Kato T, Tatsuta M, Graham DY. Possible role of Helicobacter pylori infection in early gastric cancer development. Cancer. 1994 Jun 1;73(11):2691–2694. [PubMed]
  • Crespi M, Citarda F. Helicobacter pylori and gastric cancer: what is the real risk? Gastroenterologist. 1998 Mar;6(1):16–20. [PubMed]
  • Eslick GD, Lim LL, Byles JE, Xia HH, Talley NJ. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol. 1999 Sep;94(9):2373–2379. [PubMed]
  • Hanai A, Fujimoto I. Cancer incidence in Japan in 1975 and changes of epidemiological features for cancer in Osaka. Natl Cancer Inst Monogr. 1982;62:3–7. [PubMed]
  • Hansson LE, Bergström R, Sparén P, Adami HO. The decline in the incidence of stomach cancer in Sweden 1960-1984: a birth cohort phenomenon. Int J Cancer. 1991 Feb 20;47(4):499–503. [PubMed]
  • Haruma K, Okamoto S, Kawaguchi H, Gotoh T, Kamada T, Yoshihara M, Sumii K, Kajiyama G. Reduced incidence of Helicobacter pylori infection in young Japanese persons between the 1970s and the 1990s. J Clin Gastroenterol. 1997 Dec;25(4):583–586. [PubMed]
  • Hirayama T. Epidemiology of stomach cancer in Japan. With special reference to the strategy for the primary prevention. Jpn J Clin Oncol. 1984 Jun;14(2):159–168. [PubMed]
  • Howson CP, Hiyama T, Wynder EL. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27. [PubMed]
  • LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. [PubMed]
  • Laurén PA, Nevalainen TJ. Epidemiology of intestinal and diffuse types of gastric carcinoma. A time-trend study in Finland with comparison between studies from high- and low-risk areas. Cancer. 1993 May 15;71(10):2926–2933. [PubMed]
  • Muñoz N, Connelly R. Time trends of intestinal and diffuse types of gastric cancer in the United States. Int J Cancer. 1971 Jul 15;8(1):158–164. [PubMed]
  • Muñoz N, Correa P, Cuello C, Duque E. Histologic types of gastric carcinoma in high- and low-risk areas. Int J Cancer. 1968 Nov 15;3(6):809–818. [PubMed]
  • Nikulásson S, Hallgrímsson J, Tulinius H, Sigvaldason H, Olafsdóttir G. Tumours in Iceland. 16. Malignant tumours of the stomach. Histological classification and description of epidemiological changes in a high-risk population during 30 years. APMIS. 1992 Oct;100(10):930–941. [PubMed]
  • Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991 Oct 17;325(16):1132–1136. [PubMed]
  • Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127–1131. [PubMed]
  • Parsonnet J, Vandersteen D, Goates J, Sibley RK, Pritikin J, Chang Y. Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst. 1991 May 1;83(9):640–643. [PubMed]
  • Sipponen P, Kosunen TU, Valle J, Riihelä M, Seppälä K. Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol. 1992 Apr;45(4):319–323. [PMC free article] [PubMed]
  • Talley NJ, Zinsmeister AR, Weaver A, DiMagno EP, Carpenter HA, Perez-Perez GI, Blaser MJ. Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst. 1991 Dec 4;83(23):1734–1739. [PubMed]
  • Tominaga S. Decreasing trend of stomach cancer in Japan. Jpn J Cancer Res. 1987 Jan;78(1):1–10. [PubMed]
  • Tominaga S, Kuroishi T. An ecological study on diet/nutrition and cancer in Japan. Int J Cancer. 1997;Suppl 10:2–6. [PubMed]

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