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Br J Cancer. Feb 2001; 84(3): 335–339.
PMCID: PMC2363738
Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
W K Leung,1 K-F To,2 Y-P Ng,1 T-L Lee,2 J Y W Lau,3 F K L Chan,1 E K W Ng,3 S C S Chung,3 and J J Y Sung1
1Departments of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
2Departments of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
3Departments of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Received August 7, 2000; Revised October 26, 2000; Accepted November 8, 2000.
Abstract
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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