Search tips
Search criteria 


Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
Br J Cancer. 2001 January; 84(1): 25–32.
Published online 2001 January 1. doi:  10.1054/bjoc.2000.1531
PMCID: PMC2363609

Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner


The aim of this study was to evaluate the usefulness of annual screening for lung cancer by low-dose computed tomography (CT) and the characteristics of identified lung cancers. Subjects consisted of 5483 general population aged 40–74 years, who received initial CT scans in 1996, followed by repeat annual scans for most subjects in 1997 and 1998, with a total of 13 786 scans taken during 1996–1998. Work-up examinations for patients with suspicious lesions were conducted using diagnostic CTs. The initial screening in 1996 detected suspicious nodules in 279 (5.1%) of 5483 subjects, and 22 (8%) were confirmed surgically to have lung cancer. Corresponding figures in 1997 and 1998 screening studies were 173 (3.9%) of 4425 and 25 (14%) of 173, and 136 (3.5%) of 3878 and 9 (7%) of 136, respectively. The sensitivity and specificity of detecting surgically confirmed lung cancer were 55% (22/40) and 95% (4960/5199) in 1996 and 83% (25/30) and 97% (4113/4252) in 1997 screening, respectively. 88% (55/60) of lung cancers identified on screening and surgically confirmed were AJCC stage IA. Our trial allowed detection of nearly 11 times the expected annual number of early lung cancers. Repeat CT allowed the detection of more aggressive, rapidly growing lung cancers, compared to those in the initial screening. © 2001 Cancer Research Campaign

Keywords: lung cancer, screening, low-dose computed tomography (CT)

Full Text

The Full Text of this article is available as a PDF (71K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Eddy DM. The economics of cancer prevention and detection: getting more for less. Cancer. 1981 Mar 1;47(5 Suppl):1200–1209. [PubMed]
  • Flehinger BJ, Kimmel M, Polyak T, Melamed MR. Screening for lung cancer. The Mayo Lung Project revisited. Cancer. 1993 Sep 1;72(5):1573–1580. [PubMed]
  • Henschke CI, Miettinen OS, Yankelevitz DF, Libby DM, Smith JP. Radiographic screening for cancer. Proposed paradigm for requisite research. Clin Imaging. 1994 Jan-Mar;18(1):16–20. [PubMed]
  • Henschke CI, McCauley DI, Yankelevitz DF, Naidich DP, McGuinness G, Miettinen OS, Libby DM, Pasmantier MW, Koizumi J, Altorki NK, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999 Jul 10;354(9173):99–105. [PubMed]
  • Kaneko M, Eguchi K, Ohmatsu H, Kakinuma R, Naruke T, Suemasu K, Moriyama N. Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology. 1996 Dec;201(3):798–802. [PubMed]
  • Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1998. CA Cancer J Clin. 1998 Jan-Feb;48(1):6–29. [PubMed]
  • Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest. 1997 Jun;111(6):1710–1717. [PubMed]
  • Oda M, Watanabe Y, Shimizu J, Murakami S, Ohta Y, Sekido N, Watanabe S, Ishikawa N, Nonomura A. Extent of mediastinal node metastasis in clinical stage I non-small-cell lung cancer: the role of systematic nodal dissection. Lung Cancer. 1998 Oct;22(1):23–30. [PubMed]
  • Sagawa M, Saito Y, Takahashi S, Usuda K, Kamma K, Sato M, Ota S, Nagamoto N, Fujimura S, Nakada T, et al. Clinical and prognostic assessment of patients with resected small peripheral lung cancer lesions. Cancer. 1990 Dec 15;66(12):2653–2657. [PubMed]
  • Soda H, Tomita H, Kohno S, Oka M. Limitation of annual screening chest radiography for the diagnosis of lung cancer. A retrospective study. Cancer. 1993 Oct 15;72(8):2341–2346. [PubMed]
  • Sone S, Takashima S, Li F, Yang Z, Honda T, Maruyama Y, Hasegawa M, Yamanda T, Kubo K, Hanamura K, et al. Mass screening for lung cancer with mobile spiral computed tomography scanner. Lancet. 1998 Apr 25;351(9111):1242–1245. [PubMed]
  • Sone S, Li F, Yang ZG, Takashima S, Maruyama Y, Hasegawa M, Wang JC, Kawakami S, Honda T. Characteristics of small lung cancers invisible on conventional chest radiography and detected by population based screening using spiral CT. Br J Radiol. 2000 Feb;73(866):137–145. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK