Mode of action of thiocoraline, a natural marine compound with anti-tumour activity
1Laboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche ‘Mario Negri’, via Eritrea 62, Milano, 20157, Italy
2Department of Experimental Oncology, Hollings Cancer Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC, 29425-2850, USA
3PharmaMar USA Inc., 320 Putnam Avenue, Cambridge, MA, 02139-4616, USA
4Research and Development, PharmaMar S.A., Calle de la Calera 3, Tres Cantos, Madrid, 28760, Spain
Received July 7, 1998; Revised November 19, 1998; Accepted November 27, 1998.
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Keywords: natural compound, thiocoraline, cell cycle, DNA polymerase α