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OBJECTIVES: To investigate whether sperm production has changed during the past 16 years in the Toulouse area of France. DESIGN: Time series analysis of sperm donors' specimens between 1977 and 1992. SETTING: Sperm bank of university hospital in Toulouse, France. SUBJECTS: 302 healthy fertile men candidate sperm donors more than 20 and up to 45 years old and without any infertile brothers. MAIN OUTCOME MEASURE: Spermatozoa concentration. RESULTS: Donors' mean age at time of donation was 34.05 (SD 5.13), but this increased significantly (P<0.001) during the study, from 32.4 in 1977 to 36 in 1992. Mean sperm count of samples was 83.12x10(6)/ml (SD 68.42x10(6)/ml). Sperm concentration was positively linked to the year of donation (Pearson's coefficient r=0.12, P<0.05), but this correlaton disappeared after adjustment for age of donors (r=0.09,P>0.05). CONCLUSION: Sperm concentration has not changed with time in the Toulouse area.