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J Bacteriol. Jul 1996; 178(13): 3885–3892.
PMCID: PMC232650
Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage.
M M Slupska, C Baikalov, W M Luther, J H Chiang, Y F Wei, and J H Miller
Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90024, USA.
Abstract
We have cloned the human mutY gene (hMYH) from both genomic and cDNA libraries. The human gene contains 15 introns and is 7.1 kb long. The 16 exons encode a protein of 535 amino acids that displays 41% identity to the Escherichia coli protein, which provides an important function in the repair of oxidative damage to DNA and helps to prevent mutations from oxidative lesions. The human mutY gene maps on the short arm of chromosome 1, between p32.1 and p34.3.
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