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J Clin Microbiol. 1997 November; 35(11): 2985–2988.
PMCID: PMC230103

Development of an antimicrobial susceptibility surveillance system for Neisseria gonorrhoeae in Malawi: comparison of methods.


Susceptibility of Neisseria gonorrhoeae to gentamicin, the primary treatment for gonorrhea in Malawi since 1993, was determined by using agar dilution MICs, E-test MICs, disc diffusion, and clinical cure rate. Agar dilution MICs were slightly higher in 1996 than in 1993 isolates, with a concomitant drop in the clinical cure rate. E-test MICs were substantially lower than agar dilution determinations, with only 77.4% within 1 log2 concentration.

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Selected References

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  • Andrews JM, Bradley JE, Wise R. Comparison of 'E' test with conventional agar MIC. J Antimicrob Chemother. 1993 May;31(5):802–803. [PubMed]
  • Bowie W, Ronald AR, Krywulak W, Cates CY, Boutros P. Gentamicin in the treatment of gonorrhoea in females. Br J Vener Dis. 1974 Jun;50(3):208–211. [PMC free article] [PubMed]
  • Coole L, Lees A, Swann RA. Determination of penicillin minimum inhibitory concentrations for Neisseria gonorrhoeae by the E test. J Antimicrob Chemother. 1993 Jan;31(1):173–174. [PubMed]
  • Dallabetta GA, Miotti PG, Chiphangwi JD, Saah AJ, Liomba G, Odaka N, Sungani F, Hoover DR. High socioeconomic status is a risk factor for human immunodeficiency virus type 1 (HIV-1) infection but not for sexually transmitted diseases in women in Malawi: implications for HIV-1 control. J Infect Dis. 1993 Jan;167(1):36–42. [PubMed]
  • Felarca AB, Laqui EM, Ibarra LM. Gentamicin in gonococcal urethritis of Filipino males: dosage and response. J Infect Dis. 1971 Dec;124 (Suppl):S287–S292. [PubMed]
  • Hira SK, Attili VR, Kamanga J, Mkandawire O, Patel JS, Patel MI. Efficacy of gentamicin and kanamycin in the treatment of uncomplicated gonococcal urethritis in Zambia. Sex Transm Dis. 1985 Jan-Mar;12(1):52–54. [PubMed]
  • Laga M, Nzila N, Goeman J. The interrelationship of sexually transmitted diseases and HIV infection: implications for the control of both epidemics in Africa. AIDS. 1991;5 (Suppl 1):S55–S63. [PubMed]
  • Laga M, Manoka A, Kivuvu M, Malele B, Tuliza M, Nzila N, Goeman J, Behets F, Batter V, Alary M, et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS. 1993 Jan;7(1):95–102. [PubMed]
  • Lind I. Epidemiology of antibiotic resistant Neisseria gonorrhoeae in industrialized and developing countries. Scand J Infect Dis Suppl. 1990;69:77–82. [PubMed]
  • Lule G, Behets FM, Hoffman IF, Dallabetta G, Hamilton HA, Moeng S, Liomba G, Cohen MS. STD/HIV control in Malawi and the search for affordable and effective urethritis therapy: a first field evaluation. Genitourin Med. 1994 Dec;70(6):384–388. [PMC free article] [PubMed]
  • Morrison GD, Reeves DS. Gentamicin in the treatment of gonococcal urethritis. A microbiological, pharmacological, and clinical study. Br J Vener Dis. 1973 Dec;49(6):513–516. [PMC free article] [PubMed]
  • Sanchez ML, Barrett MS, Jones RN. The E-Test applied to susceptibility tests of gonococci, multiply-resistant enterococci, and Enterobacteriaceae producing potent beta-lactamases. Diagn Microbiol Infect Dis. 1992 Jul;15(5):459–463. [PubMed]
  • Tan NJ, Rajan VS, Pang R, Sng EH. Gentamicin in the treatment of infections due to penicillinase-producing gonococci. Br J Vener Dis. 1980 Dec;56(6):394–396. [PMC free article] [PubMed]
  • Van Dyck E, Smet H, Piot P. Comparison of E test with agar dilution for antimicrobial susceptibility testing of Neisseria gonorrhoeae. J Clin Microbiol. 1994 Jun;32(6):1586–1588. [PMC free article] [PubMed]
  • Yeung KH, Ng LK, Dillon JA. Evaluation of Etest for testing antimicrobial susceptibilities of Neisseria gonorrhoeae isolates with different growth media. J Clin Microbiol. 1993 Nov;31(11):3053–3055. [PMC free article] [PubMed]

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