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BioTrove has developed the OpenArray platform based on through-hole technology, a broadly applicable nanoliter fluidics technology for parallel and low-volume solution phase reactions. OpenArray plates are coated with hydrophilic coatings on the interior of each through hole and hydrophobic coatings on the exterior of the through-holes. This enables OpenArray plates to hold solutions in the open through-holes via capillary action. The OpenArray plate consists of 3072 through-holes that can be loaded with reagents to perform individual 33 nL reactions for use in both real time PCR applications as well as endpoint genotyping applications. The unique configuration of the through-holes enables the researcher to interrogate a large number of nucleic acid samples against a large number of assays in a flexible, configurable format. By altering the number of assays or the number of samples the researcher can easily customize the OpenArray to meet their changing needs. Researchers using this technology benefit from the parallelism of microarrays and the data quality of solution phase reactions. Performance characteristics of the OpenArray platform will be presented and implications to genomic research will be discussed.