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Conventional diagnostics could benefit greatly from the high-throughput genomics technologies that have arisen over the past 10 years in basic research. Whether it is for DNA analysis (CGH arrays, SNP analysis) or RNA analysis (gene-expression arrays), information at the molecular level would undoubtedly improve the accuracy of diagnoses and prognoses. In the past 3 years, several efforts have been made to standardize assays, experimental procedures, and data processing, and governmental institutions such as the FDA, microarray manufacturers, and the scientific community have worked diligently to bring genomics into daily medicine. This talk will review the recent developments in molecular classification, prognostication, and treatments.