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It now appears that many of the health effects of exercise are influenced by the balance of stress mediators and growth factors. Related to these agents are the soluble adhesion molecules (sAM: ICAM and VCAM) and soluble selectins (sS: E, L, and P selectins) which have been linked to such illnesses as asthma and cardiovascular disease. We hypothesized that brief exercise would alter circulating levels of sAM and sS, and that the response would be modified by the child’s pubertal status. Thirty healthy males (14 early pubertal, EP; 16 late pubertal, LP) performed 10 2-min bouts of exercise on a cycle ergometer. Blood was sampled at pre-exercise (PE) and end-exercise (EE). Levels of sAM and sS were analyzed using commercially available ELISAs. Mean PE levels were significantly different between groups for ICAM (p < 0.005) and VCAM (p < 0.05), and at EE for ICAM (p < 0.005). VCAM significantly increased in response to exercise in LP males (p < 0.05). A significant change between groups was demonstrated for the selectins at PE (E and P p < 0.005; L p < 0.05) and EE (all sS p < 0.05). Only LP males demonstrated a significant change from PE to EE (all sS p < 0.05). Baseline levels of circulating vascular adhesion molecules are significantly different between healthy EP and LP males. Moreover, exercise in LP males caused a significant increase in these vascular mediators, possibly preparing the organism to adapt to stressors imposed by exercise and the vascular demands needed for muscle growth. NIH- P01HD048721, RO1HL080947, K23 ES014923-02.