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This session will address the fundamental issues in the design, analysis, and genotyping of genome-wide genetic association studies conducted to identify low-penetrance, high-frequency alleles associated with common diseases or traits. The program will review the critical issues in the epidemiologic design and collection of biospecimens for subsequent genetic analysis with high-throughput technologies for genotyping analysis. A review of current genotyping platforms and analytic strategies will highlight the spectrum of approaches towards mapping complex diseases and traits. The session will discuss currently available commercial and academic genotyping panels, as well as important considerations in genotyping strategy. Several ongoing studies will be discussed, particularly in reference to quality control, analysis, and bioinformatic support required to efficiently complete the studies. Presentations will also address statistical issues in consideration of the choice of samples and genotyping best suited to meet the scientific goals of a project.