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Biological resource centers and biorepositories provide the underpinning for advancing research and development in the life sciences. While biorepositories have been providing biological materials for many years, advancements in genomics, proteomics, and other high-technology areas are creating demands for better quality biological materials. The International Society for Biological and Environmental Repositories (ISBER) was founded in 1999 to provide a forum for biorepository managers, users, and supporters to communicate and contribute to improving the quality of biological materials. The members of ISBER include biorepositories at commercial entities, universities and hospitals, and government facilities, as well as organizations that are in the business of biological materials management such as ATCC. In 2003, ISBER published Best Practices for Repositories I, covering collection, storage, and retrieval of biospecimens, which is currently being expanded and updated. The National Cancer Institute used ISBER’s best practices to initiate the development of their First-Generation Guidelines for NCI-Supported Biorepositories, published in 2006, to try to optimize procedures and standardize management practices. ISBER is currently reaching out to other organizations that share the desire to ensure wider use of biospecimens in advancing science and medicine, and to improve the management of biological materials. ABRF can take advantage of ISBER’s role in enhancing the management and use of biological materials to provide its member organizations and their ultimate end-users with access to available biological resources.