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J Clin Microbiol. Jul 1996; 34(7): 1815–1818.
PMCID: PMC229124
Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic.
C M Chu, C T Yeh, C T Chiu, I S Sheen, and Y F Liaw
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.
Abstract
By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.
Articles from Journal of Clinical Microbiology are provided here courtesy of
American Society for Microbiology (ASM)