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The Microarray Research Group (MARG) is involved in many areas of the microarray field, with this year’s focus continuing on high-throughput gene expression. Although the focus has traditionally centered around high-throughput gene expression, the group plans on expanding its milieu to include other microarray-based technologies that are important for discovery in the genomics arena. Currently three large studies are in progress through the MARG. The group has conducted a large retrospective study of the variability that contributes to Affymetrix Gene Chip technology, and we will be publishing those results as well as launching a reference database from that study shortly. This year the group switched gears to investigate the important aspects of oligonucleotide library design for their use in microarray analysis. Replicate labeling and hybridization protocols were run in nine ABRF Microarray core laboratories to generate a data set that will help distinguish the important components of oligonucleotide design, synthesis, purification, and performance in a gene expression study. This body of work will be presented during the Research Group session at the 2003 ABRF meeting. Lastly, the MARG has launched the latest edition of its comprehensive microarray core facility survey. This year’s survey covers both commercial and home-grown technologies in the hopes of redefining the state of the art as it pertains to high-throughput gene expression using microarray-based technologies and services. The results of the survey will be presented in a poster at ABRF 2003.
The members of the MARG sincerely appreciate all of the academic and industrial support it has received throughout 2002 and would like to thank everyone who has contributed data to all of our studies.