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Bioinorg Chem Appl. 2003; 1(3-4): 227–231.
PMCID: PMC2267064
Communication: Synthesis of a Novel Triphenyltin(IV) Derivative of 2- Mercaptonicotinic Acid with Potent Cytotoxicity in vitro
Marianna N. Xanthopoulou,1 Sotiris K. Hadjikakou,1 Nick Hadjiliadis,1 Markus Schürmann,2 Klaus Jurkschat,2 Jayne Binolis,3 Spyros Karkabounas,3 and Konstantinos Charalabopoulos3
1 Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, Ioannina, 45110, Greece,
2 Lehrstuhl für Anorganische Chemie II der Universität Dortmund, Dortmund, 44221, Germany,
3 Department of Experimental Physiology, Medical School, University of Ioannina, Ioannina, 45110, Greece,
Abstract
A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (H2mna) of formula {[(C6H5)3Sn]2(mna).[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 1H, 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (H>2mna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
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