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Mol Med. 1997 June; 3(6): 356–358.
PMCID: PMC2230204

The Werner mutation: does it lead to a "public" or "private" mechanism of aging?

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Selected References

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  • Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, et al. Positional cloning of the Werner's syndrome gene. Science. 1996 Apr 12;272(5259):258–262. [PubMed]
  • Oshima J, Yu CE, Piussan C, Klein G, Jabkowski J, Balci S, Miki T, Nakura J, Ogihara T, Ells J, et al. Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet. 1996 Dec;5(12):1909–1913. [PubMed]
  • Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 1966 May;45(3):177–221. [PubMed]
  • Stadtman ER, Oliver CN. Metal-catalyzed oxidation of proteins. Physiological consequences. J Biol Chem. 1991 Feb 5;266(4):2005–2008. [PubMed]
  • Cohen JI, Arnett EN, Kolodny AL, Roberts WC. Cardiovascular features of the Werner syndrome. Am J Cardiol. 1987 Feb 15;59(5):493–495. [PubMed]
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  • Yu CE, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu YH, Mulligan J, Martin GM, et al. Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet. 1997 Feb;60(2):330–341. [PubMed]
  • Martin GM, Sprague CA, Epstein CJ. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest. 1970 Jul;23(1):86–92. [PubMed]
  • Oshima J, Campisi J, Tannock TC, Martin GM. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol. 1995 Feb;162(2):277–283. [PubMed]
  • Poot M, Hoehn H, Rünger TM, Martin GM. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res. 1992 Oct;202(2):267–273. [PubMed]
  • Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, Martin GM. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet. 1996 Jun;97(6):750–754. [PubMed]
  • Martin GM, Austad SN, Johnson TE. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet. 1996 May;13(1):25–34. [PubMed]
  • Hoehn H, Bryant EM, Au K, Norwood TH, Boman H, Martin GM. Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet. 1975;15(5):282–298. [PubMed]
  • Salk D, Au K, Hoehn H, Martin GM. Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet. 1981;30(2):92–107. [PubMed]
  • Fukuchi K, Martin GM, Monnat RJ., Jr Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5893–5897. [PubMed]
  • Fukuchi K, Tanaka K, Kumahara Y, Marumo K, Pride MB, Martin GM, Monnat RJ., Jr Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet. 1990 Feb;84(3):249–252. [PubMed]
  • Rünger TM, Bauer C, Dekant B, Möller K, Sobotta P, Czerny C, Poot M, Martin GM. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol. 1994 Jan;102(1):45–48. [PubMed]
  • Ye L, Miki T, Nakura J, Oshima J, Kamino K, Rakugi H, Ikegami H, Higaki J, Edland SD, Martin GM, et al. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet. 1997 Feb 11;68(4):494–498. [PubMed]

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