Search tips
Search criteria 


Logo of molmedLink to Publisher's site
Mol Med. 1997 February; 3(2): 90–93.
PMCID: PMC2230059

Association between the serotonin transporter gene and affective disorder: the evidence so far.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (511K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • DeMyer MK, Shea PA, Hendrie HC, Yoshimura NN. Plasma tryptophan and five other amino acids in depressed and normal subjects. Arch Gen Psychiatry. 1981 Jun;38(6):642–646. [PubMed]
  • Salomon RM, Miller HL, Delgado PL, Charney D. The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders. Int Clin Psychopharmacol. 1993 Nov;8 (Suppl 2):41–46. [PubMed]
  • Ferrier IN, Eccleston D, Moore PB, Wood KA. Relapse in chronic depressives on withdrawal of L-tryptophan. Lancet. 1990 Aug 11;336(8711):380–381. [PubMed]
  • Maj M, Mastronardi P, Cerreta A, Romano M, Mazzarella B, Kemali D. Changes in platelet 3H-imipramine binding in depressed patients receiving electroconvulsive therapy. Biol Psychiatry. 1988 Aug;24(4):469–472. [PubMed]
  • KUHN R. The treatment of depressive states with G 22355 (imipramine hydrochloride). Am J Psychiatry. 1958 Nov;115(5):459–464. [PubMed]
  • Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P. Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect. 1993;91(1):67–72. [PubMed]
  • Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2542–2546. [PubMed]
  • Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry. 1995 Feb 15;37(4):215–223. [PubMed]
  • Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect. 1994;95(2):157–162. [PubMed]
  • Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM, Smith CA. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet. 1996 Mar 16;347(9003):731–733. [PubMed]
  • Kunugi H, Tatsumi M, Sakai T, Hattori M, Nanko S. Serotonin transporter gene polymorphism and affective disorder. Lancet. 1996 May 11;347(9011):1340–1340. [PubMed]
  • Stöber G, Heils A, Lesch KP. Serotonin transporter gene polymorphism and affective disorder. Lancet. 1996 May 11;347(9011):1340–1341. [PubMed]
  • Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P, Aitchison KJ, Sodhi M, Li T, Roberts GW, et al. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport. 1996 Jul 8;7(10):1675–1679. [PubMed]
  • Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996 Jun;66(6):2621–2624. [PubMed]
  • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996 Nov 29;274(5292):1527–1531. [PubMed]
  • Jardine R, Martin NG, Henderson AS. Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genet Epidemiol. 1984;1(2):89–107. [PubMed]

Articles from Molecular Medicine are provided here courtesy of The Feinstein Institute for Medical Research at North Shore LIJ