1. A. Finlay, and R. Marks. Determination of corticosteroid concentration profile in the stratum corneum using the skin surface biopsy technique. Br. J. Derm.107Suppl 22:23 (1982).
2. P. M. Elias. Epidermal lipids, barrier function and desquamation. J. Invest. Dermatol.80:S44–S49 (1983). [PubMed] 3. P. W. Wertz, D. C. Swartzendruber, D. J. Kitko, K. C. Madison, and D. T. Downing. The role of the corneocytes lipid envelopes in cohesion of the stratum corneum. J. Invest. Dermatol.93:169–172 (1989). [PubMed]
4. P. M. Elias. Epidermal barrier function: intercellular lamellar lipid structures, origin, composition and metabolism. J. Control. Release15:199–208 (1991).
5. R. L. Anderson, and J. M. Cassidy. Variations in physical dimensions and chemical composition of human stratum corneum. J. Invest. Dermatol.61:30–32 (1973). [PubMed] 6. K. Holbrook, and G. Odland. Regional differences in the thickness of the human stratum corneum: an ultrastructural analysis. J. Invest. Dermatol.62:415–422 (1974). [PubMed] 7. D. Schwindt, K. P. Wilhelm, and H. I. Maibach. Water diffussion characteristics of human stratum corneum at different anatomical sites in vivo. J. Invest. Dermatol.111:385–389 (1998). [PubMed]
8. M. Fartasch. The nature of the epidermal barrier: structural aspects. Adv. Drug Deliv. Rev.18:273–282 (1996).
9. N. A. Monteiro-Riviere. Introduction to histological aspects of dermatotoxicology. Microsc. Res. Tech.37:171 (1997). [PubMed] 10. S. Borsadia, A. H. Ghanem, Y. Seta, W. I. Higuch, G. L. Flynn, C. R. Behl, and V. P. Shah. Factors to be considered in the evaluation of bioavailability and bioequivalence of topical formulations. Skin Pharmacol.5:129–145 (1992). [PubMed]
11. C. R. Behl, H. Char, S. B. Patel, D. B. Metha, D. Piemontese, and A. W. Malick. In vivo and in vitro skin uptake and permeation studies: critical considerations and factors which affect them. In V. P. Shah and H. I. Maibach (eds.), Topical Drug Bioavailability, Bioequivalence, and Penetration, Plenum, New York, 1993, pp. 225–252.
12. R. Marks, and P. Dykes. Plasma and cutaneous drug levels after topical application of piroxicam gel: a study in healthy volunteers. Skin Pharmacol.7:340–344 (1994). [PubMed] 13. R. O. Potts, and R. H. Guy. Predicting skin permeability. Pharm. Res.9:663–669 (1992). [PubMed] 14. D. Dupuis, A. Rougier, R. Roguet, and C. Lotte. The measurement of the stratum corneum reservoir: a simple method to predict the influence of vehicles on in vivo percutaneous absorption. Br. J. Derm.115:233–238 (1986). [PubMed]
15. G. L. Flynn. General introduction and conceptual differentiation of topical and transdermal drug delivery systems. Differentiation with respect to delivery kinetics. In V. P. Shah and H. I. Maibach (eds.), Topical Drug Bioavailability, Bioequivalence, and Penetration, Plenum, New York, 1993, pp. 369–392.
16. L. K. Pershing, B. S. Silver, G. G. Krueger, V. P. Shah, and J. P. Skelley. Feasibility of measuring the bioavailability of topical betamethasoe dipropionate in commercial formulation using drug content in skin and a skin blanching bioassay. Pharm. Res.9:45–51 (1992). [PubMed]
17. A. W. McKenzie, and Stoughton R. B. Method of comparing percutaneous absorption of steroids. Arch. Dermatol.86:608–610 (1962).
18. J. M. Haigh, and I. Kanfer. Assessment of topical corticosteroid preparations: the human skin blanching assay. Int. J. Pharm.19:245–262 (1984).
19. S. Y. Chan, and A. Li Wan Po. Quantitative skin blanching assay of corticosteroid creams using tristimulus colour analysis. J. Pharm. Pharmacol.44:371–378 (1992). [PubMed]
20. L. K. Pershing, L. D. Lambert, V. P. Shah, and S. Y. Lam. Variability and correlation of chromameter and tape-stripping methods with the visual skin blanching assay in the quantitative assessment of topical 0.05% betamethasone dipropionate bioavailability in humans. Int. J. Pharm.86:201–210 (1992).
21. V. P. Shah. Topical dermatological drug product NDAs and ANDAs—in vivo bioavailability, bioequivalence, in vitro release and associated studies, US Dept. of Health and Human Services, Rockville, 1998, pp. 1–19.
22. L. K. Pershing, S. Bakhtian, G. Poncelet, J. L. Corlett, and V. P. Shah. Comparison of skin stripping, in vitro release, and skin blanching response methods to measure dose response and similarity of triamcinolone acetonide cream strengths from two manufactured sources. J. Pharm. Sci.91:1312–1323 (2002). [PubMed] 23. J. Johannson, and A. Lahti. Topical non-steroidal anti-inflammatory drugs inhibit non-immunologic immediate contact reactions. Contact Dermatitis19:161–165 (1988). [PubMed] 24. M. C. Poelman, B. Piot, F. Guyon, M. Deroni, and J. L. Leveque. Assessment of topical non-steroidal anti-inflammatory drugs. J. Pharm. Pharmacol.41:720–722 (1989). [PubMed] 25. L. Duteil, C. Queille, M. Poncet, J. P. Ortonne, and J. Czernielewski. Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation. Clin. Exp. Dermatol.15:195–199 (1990). [PubMed] 26. S. Y. Chan, and A. Li Wan Po. Quantitative evaluation of drug-induced erythema using a tristimulus color analyzer: experimental design and data analysis. Skin Pharmacol.6:298–312 (1994). [PubMed] 27. P. Treffel, and B. Gabard. Feasibility of measuring the bioavailability of topical ibuprofen in commercial formulations using drug content in epidermis and a methyl nicotinate skin inflammation assay. Skin Pharmacol.6:268–275 (1994). [PubMed] 28. H. Tagami, T. Tadaki, M. Obata, and J. Koyama. Functional assessment of the stratum corneum under the influence of oral aromatic retinoid (etretinate) in guinea-pigs and humans. Comparison with topical retinoic acid treatment. Br. J. Dermatol.127:470–475 (1992). [PubMed] 29. J. W. Fluhr, M. P. Vienne, C. Lauze, P. Dupuy, W. Gehring, and M. Gloor. Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. Dermatol.199(Suppl 1):57–60 (1999). [PubMed] 30. M. Vershoore, M. Poncet, J. Czernielewki, V. Sorba, and A. Clucas. Adapalene 0.1% gel has low skin-irritation potential. J. Am. Acad. Dermatol.36:S104–S109 (1997). [PubMed] 31. V. P. Shah. Bioequivalence of topical dermatological dosage forms—methods of evaluation of bioequivalence. Pharm. Res.15:167–171 (1998). [PubMed] 32. G. K. Menon, K. R. Feingold, and P. M. Elias. Lamellar body secretory response to barrier disruption. J. Invest. Dermatol.98:279–289 (1998). [PubMed] 33. M. Denda, L. C. Wood, S. Emami, C. Calhoun, B. E. Brown, P. M. Elias, and K. R. Feingold. The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss. Arch. Dermatol. Res.288:230–238 (1996). [PubMed] 34. P. G. Van der Walk and H. I. Maibach. A functional study of the skin barrier to evaporative water loss by means of repeated cellophane-tape stripping. Clin. Exp. Dermatol.15:180–182 (1990). [PubMed] 35. C. Pierard-Franchimont, and G. E. Pierard. Assessment of aging and actinic damages by cyanoacrylate skin surface strippings. Am. J. Dermatopathol.9:500–509 (1987). [PubMed] 36. C. Marionnet, F. Bernerd, A. Dumas, F. Verrecchia, K. Mollier, D. Compan, B. Bernard, M. Lahfa, J. Leclaire, C. Medaisko, B. Mehul, S. Seite, A. Mauviel, and L. Dubertret. Modulation of gene expression induced in human epidermis by environmental stress in vivo. J. Invest. Dermatol.121:1447–1458 (2003). [PubMed] 37. H. Ou-Yang, G. Stamatas, C. Saliou, and N. Kollias. A chemiluminescence study of UVA-induced oxidative stress in human skin in vivo. J. Invest. Dermatol.122:1020–1029 (2004). [PubMed] 38. H. Wagner, K. H. Kostka, C. M. Lehr, and U. F. Schaefer. pH profiles in human skin: influence of two in vitro test systems for drug delivery testing. Eur. J. Pharm. Biopharm.55:57–65 (2003). [PubMed] 39. N. Sekkat, Y. N. Kalia, and R. H. Guy. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J. Pharm. Sci.91:2376–2381 (2002). [PubMed] 40. J. Inoue, and Y. Aramaki. Toll-like recptor 9 induced by tape-stripping triggers on effective immune response with CpG-oligodeoxynucleotides. Vaccine25:1007–1013 (2006). [PubMed]
41. C. Surber, F. P. Schwarb, and E. W. Smith. Tape-stripping technique. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption, Dekker, New York, 1999, pp. 395–409.
42. P. W. Lücker, E. Beubler, W. R. Kukovetz, and W. Ritter. Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica169:51–55 (1984). [PubMed] 43. L. K. Pershing, J. Corlett, and C. Jorgensen. In vivo pharmacokinetics and pharmacodynamic of topical ketoconazole in human stratum corneum. Antimicrob. Agents. Chemother.38:90–95 (1994). [PMC free article] [PubMed] 44. I. Alberti, Y. N. Kalia, A. Naik, J. D. Bonny, and R. H. Guy. In vivo assessment of the enhanced topical delivery of terbinafine to human stratum corneum. J. Control Release71:319–327 (2001). [PubMed] 45. I. Alberti, Y. N. Kalia, A. Naik, J. D. Bonny, and R. H. Guy. Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum in vivo. Int. J. Pharm.219:11–19 (2001). [PubMed] 46. I. Alberti, Y. N. Kalia, A. Naik, and R. H. Guy. Assessment and prediction of the cutaneous bioavailability of topical terbinafine in vivo in man. Pharm. Res.18:1472–1475 (2001). [PubMed] 47. P. Clarys, B. Gabard, R. Lambrecht, A. Barel, E. Bieli, and S. Lüdi. There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum. J. Dermatol. Sci.27:77–81 (2001). [PubMed] 48. C. Fernandez, F. Nielloud, R. Fortuné, L. Vian, and G. Marti-Mestres. Benzophenone-3: rapid prediction and evaluation using non-invasive methods of in vivo human penetration. J. Pharm. Biomed. Anal.28:57–63 (2002). [PubMed] 49. S. A. Wissing, and R. H. Müller. Solid lipid nanoparticles as carriers for sunscreens: in vitro release and in vivo skin penetration. J. Control Release81:225–233 (2002). [PubMed] 50. U. Jacobi, H. Weigmann, M. Baumann, A. Reiche, W. Sterry, and J. Lademann. Lateral spreading of topically applied UV filter substances investigated by tape stripping. Skin Pharmacol. Appl. Skin Physiol.17:17–22 (2004). [PubMed] 51. V. Sarveiya, S. Risk, and H. A. E. Benson. Liquid chromatographic assay for common sunscreen agents : application to in vivo assessment of skin penetration and systemic absorption in human volunteers. J. Chrom. B803:225–231 (2004). [PubMed] 52. H. Lboutounne, J. F. Chaulet, C. Ploton, F. Falson, and F. Pirot. Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(-caprolactone) nanocapsule encapsulated form and as a digluconate. J. Control Release82:319–334 (2002). [PubMed] 53. A. Rougier, D. Dupuis, C. Lotte, R. Roguet, and H. Schaefer. In vivo correlation between stratum corneum reservoir function and percutaneous absorption. J. Invest. Dermatol.81:275–278 (1983). [PubMed] 54. A. Rougier, C. Lotte, and H. I. Maibach. The measurement of the stratum corneum reservoir. A predictive method for in vivo percutaneous absorption studies: influence of application time. J. Invest. Dermatol.83:460–462 (1984). [PubMed]
55. A. Rougier, C. Lotte, and D. Dupuis. An original predictive method for in vivo percutaneous absorption studies. J. Soc. Cos. Chem.38:397–417 (1987).
56. A. Rougier, C. Lotte, and H. I. Maibach. In vivo percutaneous penetration of some organic compounds related to anatomic site in humans: predictive assessment by the stripping method. J. Pharm. Sci.76:451–454 (1987). [PubMed] 57. D. Caron, C. Queille-Roussel, V. P. Shah, and H. Schaefer. Correlation between the drug penetration and the blanching effect of topically applied hydrocortisone creams in human beings. J. Am. Acad. Dermatol.23:458–462 (1990). [PubMed] 58. N. V. Sheth, M. B. McKeough, and S. L. Spruance. Measurements of the stratum corneum drug reservoir. J. Invest. Dermatol.89:598–602 (1987). [PubMed] 59. C. Curdy, Y. N. Kalia, A. Naik, and R. H. Guy. Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion. J. Control Release76:73–79 (2001). [PubMed]
60. N. Keiko, and Y. Toshiko. Volatilization of menthol, camphor and methyl salicylate from analgesic anti-inflammatory cataplasms and plasters. Yakuzaigaku.47:168–175 (1987).
61. N. Goetz, G. Kaba, D. Good, G. Hussler, and P. Bore. Detection and identification of volatile compounds evolved from human hair and scalp using headspace gas chromatography. J. Soc. Cosmet. Chem.39:1–13 (1988).
62. F. Pragst, V. Auwarter, B. Kiessling, and C. Dyes. Wipe-test and patch-test for alcohol misuse based on the concentration ratio of fatty acid ethyl esters and squalene CFAEE/CSQ in skin surface lipids. Forensic. Sci. Int.143:77–86 (2004). [PubMed] 63. D. A. Bucks, J. J. Hostynek, R. S. Hinz, and R. H. Guy. Uptake of two zwitterionic surfactants into human skin in vivo. Toxicol. Appl. Pharmacol.120:224–227 (1993). [PubMed] 64. F. Pirot, Y. N. Kalia, A. L. Stinchcomb, G. Keating, A. Bunge, and R. H. Guy. Characterization of the permeability barrier of human skin in vivo. Proc. Natl. Acad. Sci. U. S. A.94:1562–1567 (1997). [PubMed] 65. M. B. Reddy, A. L. Stinchcomb, R. H. Guy, and A. L. Bunge. Determining dermal absorption parameters in vivo from tape strip data. Pharm. Res.19:292–298 (2002). [PubMed] 66. H. A. Ayala-Bravo, D. Quintanar-Guerrero, A. Naik, Y. N. Kalia, J. M. Cornejo-Bravo, and A. Ganem-Quintanar. Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability. Pharm. Res.20:1267–1273 (2003). [PubMed] 67. H. C. Tsai, C. Y. Lin, H. M. Sheu, Y. L. Lo, and Y. H. Huang. Noninvasive characterization of regional variation in drug transport into human stratum corneum in vivo. Pharm. Res.20:632–638 (2003). [PubMed] 68. V. P. Shah, G. L. Flynn, R. H. Guy, H. I. Maibach, H. Schaefer, J. P. Skelly, R. C. Wester, and A. Yacobi. In vivo percutaneous penetration/absorption. Pharm. Res.8:1071–1075 (1991). [PubMed]
69. Y. C. Huang, L. Lesko, P. Schwartz, V. P. Shah, and R. Williams. Topical and transdermal generic drug products: regulatory issues and resolution. In K. R. Brain, K. A. Walters, and V. J. James (eds.), Prediction of Percutaneous Penetration, vol 3B, STS, Cardiff, 1993, pp. 463–472.
70. S. Shah, D. Hare, S. V. Dighe, and R. L. Williams. Bioequivalence of topical dermatological products. In Shah V. P., and Maibach H. I. (eds.), Topical Drug Bioavailability, Bioequivalence and Penetration, Plenum, New York, 1993, pp. 393–413.
71. V. P. Shah. Challenges in evaluating bioequivalence of dermatological drug products. In C. Surber, P. Elsner, and A. J. Birhcer (eds.), Exogenous Dermatology. Curr Prob Dermatol, Karger, Basel, 1995, pp. 152–157. [PubMed] 72. L. K. Pershing, J. L. Nelson, J. L. Corlett, S. P. Shrivastava, D. B. Hare, and V. P. Shah. Assessment of dermatopharmacokinetic approach in the bioequivalence determination of topical gel products. J. Am. Acad. Dermatol.48:740–751 (2003). [PubMed]
74. T. J. Franz. Study #1, Avita Gel 0.025% vs Retin-A Gel 0.025%, Advisory Committee for Pharmaceutical Sciences Meeting, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Rockville, MD, 2001 (November 29).
75. L. K. Pershing. Bioequivalence Assessment of three 0.025% tretinoin gel products: Dermatopharmacokinetic vs. Clinical Trial Methods, Advisory Committee for Pharmaceutical Sciences Meeting, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Rockville, MD, 2001 (November 29).
76. E. Chatelain, B. Gabard, and C. Surber. Skin penetration and sun protection factor of five UV filters: effect of the vehicle. Skin Pharmacol. Appl. Skin Physiol.16:28–35 (2003). [PubMed] 77. R. Marks, and R. P. Dawber. Skin surface biopsy: an improved technique for the examination of the horny layer. Br. J. Derm.84:117–123 (1971). [PubMed] 78. J. M. Lachapelle, J. C. Gouverneur, M. Boulet, and D. Tennstedt. A modified technique (using polyester tape) of skin surface biopsy. Its interest for the investigation of athlete’s foot. Br. J. Dermatol.97:49–52 (1977). [PubMed] 79. Y. N. Kalia, F. Pirot, and R. H. Guy. Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo. Biophys. J.71:2692–2700 (1996). [PubMed] 80. Y. N. Kalia, I. Alberti, N. Sekkat, C. Curdy, A. Naik, and R. H. Guy. Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharm. Res.17:1148–1150 (2000). [PubMed] 81. E. Marttin, M. T. A. Neelissen-Subnel, F. H. N. De Haan, and H. E. Boddé. A critical comparison of methods to quantify stratum corneum removed by tape stripping. Skin Pharmacol.9:69–77 (1996). [PubMed] 82. F. Dreher, A. Arens, J. J. Hostynek, S. Mudumba, J. Ademola, and H. I. Maibach. Colorimetric method for quantifying Human stratum corneum removed by adhesive tape stripping. Acta Derm. Venereol.78:186–189 (1998). [PubMed] 83. H. J. Weigmann, J. Lademann, H. Meffert, H. Schaefer, and W. Sterry. Determination of the horny layer profile by tape stripping in combination with optical spectroscopy in the visible range as a prerequisite to quantify percutaneous absorption. Skin Pharmacol. Appl. Skin Physiol.12:34–45 (1999). [PubMed] 84. U. Lindemann, H. J. Weigmann, H. Schaefer, W. Sterry, and J. Lademann. Evaluation of the pseudo-absorption method to quantify human stratum corneum removed by tape stripping using protein absorption. Skin Pharmacol. Appl. Skin Physiol.16:228–236 (2003). [PubMed] 85. H. J. Weigmann, U. Lindemann, C. Antoniou, G. N. Tsikrikas, A. I. Stratigos, A. Katsambas, W. Sterry, and J. Lademann. UV/VIS absorbance allows rapid, accurate and reproductible mass determination of corneocytes removed by tape stripping. Skin Pharmacol. Appl. Skin Physiol.16:217–227 (2003). [PubMed] 86. Y. Chao, F. Nylander, and A. Leena. Determination of keratin protein in a tape-stripped skin sample from jet fuel exposed skin. Ann. Occup. Hyg.48:65–73 (2004). [PubMed]
87. N. A. Puttnam. Attenuated total reflectance studies of the skin. J. Soc. CosmetChem.23:209–226 (1972).
88. H. M. Klimisch, and G. Chandra. Use of Fourier transform infrared spectroscopy with attenuated total reflectance for in vivo quantification of PDMS on human skin. J. Soc. Cosmet. Chem.37:73–87 (1986).
89. V. H. W. Mak, R. O. Potts, and R. H. Guy. Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm. Res.7:835–841 (1990). [PubMed]
90. D. Bommannan, R. Potts, and R. H. Guy. Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy. J. Control Release16:299–304 (1991).
91. N. Higo, A. Naik, D. B. Bommannan, R. O. Potts, and R. H. Guy. Validation of reflectance of reflectance infrared spectroscopy as a quantitative method to measure percutaneous absorption in vivo. Pharm. Res.10:1500–1506 (1993). [PubMed] 92. D. Bommannan, R. Potts, and R. H. Guy. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J. Invest. Dermatol.95:403–408 (1990). [PubMed] 93. M. Dias, J. Hadgraft, S. L. Raghavan, and J. Tetteh. The effect of solvent on permeant diffusion through membranes studied using ATR-FTIR and chemometric data analysis, J. Pharm. Sci.93:186–196 (2004). [PubMed] 94. C. Herkenne, A. Naik, Y. N. Kalia, J. Hadgraft, and R. H. Guy. Dermatopharmacokinetic prediction of topical drug bioavailability in vivo. J. Invest. Dermatol.127:887–894 (2007). [PubMed]
95. M. S. Roberts, Y. G. Anissimov, and R. A. Gonsalvez. Mathematical models in percutaneous absorption. In R. L. Bronaugh and H. I. Maibach (eds.), Percutaneous Absorption. Drugs, Cosmetics, Mechanisms, Methodology, Dekker, New York, 1999, pp. 3–55.
96. J. Lademann, N. Otberg, H. Richter, U. Jacobi, H. Schaefer, U. Blume-Peytavi, and W. Sterry. Follicular penetration. An important pathway for topically applied substances. Der Hautarzt54:321–323 (2003). [PubMed] 97. J. Lademann, H. Schaefer, N. Otberg, A. Teichmann, U. Blume-Peytavi, and W. Sterry. Penetration of microparticles into human skin. Der Hautarzt55:1117–1119 (2004). [PubMed] 98. R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, and U. Blume-Peytavi. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J. Invest. Dermatol.123:168–176 (2004). [PubMed] 99. A. Teichmann, U. Jacobi, M. Ossadnik, H. Richter, S. Koch, W. Sterry, and J. Lademann. Differential stripping: determination of the amount of topically applied substances penetrated into hair follicles. J. Invest. Dermatol.125:264–269 (2005). [PubMed] 100. M. Kreilgraad. Assessment of cutaneous drug delivery using microdialysis. Adv. Drug Deliv. Rev.54:99–121 (2002). [PubMed] 101. E. Schnetz, and M. Fartasch. Microdialysis for the evaluation of penetration through the human skin barrier—a promising tool for future research? Eur. J. Pharm. Sci.12:165–174 (2001). [PubMed] 102. P. Lonnroth, P. A. Jansson, and U. Smith. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol.253:E228–231 (1987). [PubMed] 103. J. M. Ault, C. M. Riley, N. M. Meltzer, and C. E. Lunte. Dermal microdialysis sampling in vivo. Pharm. Res.11:1631–1639 (1994). [PubMed] 104. F. X. Mathy, R. K. Verbeeck, and V. Préat. Validation of subcutaneous microdialysis sampling for pharmacokinetic studies on flurbiprofen in the rat. J. Pharm. Sci.90:1897–1906 (2001). [PubMed] 105. L. Stahle. On mathematical models of microdialysis: geometry, steady-state models, recovery and probe radius. Adv. Drug Deliv. Rev.45:149–167 (2000). [PubMed] 106. G. Fettweis, and J. Borlak. Topics in xenobiochemistry-application of microdialysis techniques in pharmacokinetic studies. Xenobiotica26:473–485 (1996). [PubMed] 107. M. Kreilgaard. Dermal pharmacokinetics of microemulsion formulations determined by in vivo microdialysis. Pharm. Res.18:367–373 (2001). [PubMed] 108. S. E. Cross, C. Anderson, M. J. Thompson, and M. S. Roberts. Is there tissue penetration after application of topical salicylate formulations? Lancet350:636 (1997). [PubMed] 109. S. E. Cross, C. Anderson, and M. S. Roberts. Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. Br. J. Clin. Pharmacol.46:29–35 (1998). [PubMed] 110. E. Benfeldt, J. Serup, and T. Menné. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Br. J. Dermatol.140:739–748 (1999). [PubMed] 111. F.-X. Mathy, C. Lombry, R. K. Verbeeck, and V. Préat. Study of the percutaneous penetration of flurbiprofen by cutaneous and subcutaneous microdialysis after iontophoretic delivery in rat. J. Pharm. Sci. 94:144–152 (2005). [PubMed] 112. F.-X. Mathy, D. Ntivunwa, R. K. Verbeeck, and V. Préat. Fluconazole distribution in rat dermis following intravenous and topical application: a microdialysis study. J. Pharm. Sci.94:770–780 (2005). [PubMed] 113. D. McCleverty, R. Lyons, and B. Henry. Microdialysis sampling and the clinical determination of topical dermal bioequivalence. Int. J. Pharm.308:1–7 (2006). [PubMed] 114. K. Matsuyama, M. Nakashima, M. Ichikawa, T. Yano, S. Satoh, and S. Goto. In vivo microdialysis for the transdermal absorption of valproate in rats. Biol. Pharm. Bull.17:1395–1398 (1994). [PubMed] 115. K. Matsuyama, M. Nakashima, Y. Nakaboh, M. Ichikawa, T. Yano, and S. Satoh. Application of in vivo microdialysis to transdermal absorption of methotrexate in rats. Pharm. Res.11:684–686 (1994). [PubMed] 116. M. Nakashima, M. F. Zhao, H. Ohya, M. Sakurai, H. Sasaki, K. Matsuyama, and M. Ichikawa. Evaluation of in vivo transdermal absorption of cyclosporin with absorption enhancer using intradermal microdialysis in rats. J. Pharm. Pharmacol.48:1143–1146 (1996). [PubMed] 117. T. Murakami, M. Yoshioka, R. Yumoto, Y. Higashi, S. Shigeki, Y. Ikuta, and N. Yata. Topical delivery of keloid therapeutic drug, tranilast, by combined use of oleic acid and propylene glycol as a penetration enhancer: evaluation by skin microdialysis in rats. J. Pharm. Pharmacol.50:49–54 (1998). [PubMed] 118. T. Murakami, M. Yoshioka, I. Okamoto, R. Yumoto, Y. Higashi, K. Okahara, and N. Yata. Effect of ointment bases on topical and transdermal delivery of salicylic acid in rats: evaluation by skin microdialysis. J. Pharm. Pharmacol.50:55–61 (1998). [PubMed] 119. J. Y. Fang, L. R. Hsu, Y. B. Huang, and Y. H. Tsai. Evaluation of transdermal iontophoresis of enoxacin from polymer formulations: in vitro skin permeation and in vivo microdialysis using Wistar rat as an animal model. Int. J. Pharm.180:137–149 (1999). [PubMed] 120. J. Y. Fang, K. C. Sung, H. H. Lin, and C. L. Fang. Transdermal iontophoretic delivery of diclofenac sodium from various polymer formulations: in vitro and in vivo studies. Int. J. Pharm.178:83–92 (1999). [PubMed]
121. J. Y. Fang, C. T. Kuo, C. L. Fang, Y. B. Huang, and Y. Tsai. Transdermal iontophoresis of sodium nonivamide acetate evaluated by in vivo microdialysis and histologic study. Drug Dev. Res.46:87–95 (1999).
122. P. Ding, H. Xu, G. Wei, and J. Zheng. Microdialysis sampling coupled to HPLC for transdermal delivery study of ondansetron hydrochloride in rats. Biomed. Chromatogr.14:141–143 (2000). [PubMed] 123. E. Benfeldt, and J. Serup. Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Arch. Dermatol. Res.291:517–526 (1991). [PubMed] 124. C. Anderson, T. Andersson, and M. Molander. Ethanol absorption across human skin measured by in vivo microdialysis technique. Acta Derm. Venerol (Stockh) 71:389–393 (1991). [PubMed] 125. W. F. Elmquist, and R. J. Sawchuk. Application of microdialysis in pharmacokinetic studies. Pharm. Res.14:267–288 (1997). [PubMed] 126. D. K. Hansen, M. I. Davies, S. Lunte, and C. E. Lunte. Pharmacokinetic and metabolism studies using microdialysis sampling. J. Pharm. Sci.88:14–27 (1999). [PMC free article] [PubMed] 127. L. Hegemann, C. Forstinger, B. Partsch, I. Lagler, S. Krotz, and K. Wolff. Microdialysis in cutaneous pharmacology: Kinetic analysis of transdermally delivered nicotine. J. Invest. Dermatol.104:839–843 (1995). [PubMed]
128. M. Müller, R. Schmid, O. Wagner, B. Osten, H. Shayganfar, and H. G. Eichler. In vivo characterization of transdermal drug transport by microdialysis. J. Control Release37:49–57 (1995).
129. E. Benfeldt, and L. Groth. Feasibility of measuring lipophilic or protein-bound drugs in the dermis by in vivo microdialysis after topical or systemic drug administration. Acta Derm. Venereol.78:274–278 (1998). [PubMed] 130. M. Müller, H. Mascher, C. Kikuta, S. Schäfer, M. Brunner, G. Dorner, and H. G. Eichler. Diclofenac concentrations in defined tissue layers after topical administration. Clin. Pharmacol. Ther.62:293–299 (1997). [PubMed] 131. M. Müller, M. Brunner, R. Schmid, E. M. Putz, A. Schmiedberger, I. Wallner, and G. Eichler. Comparison of three different experimental methods for the assessment of peripheral compartment pharmacokinetic in humans. Life Sci.62:227–234 (1998). [PubMed] 132. I. Tegeder, U. Muth-Selbach, J. Lötsch, G. Rüsing, R. Oelkers, K. Brune, S. Meller, G. R. Kelm, F. Sörgel, and G. Geisslinger. Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration. Clin. Pharmacol. Ther.65:357–368 (1999). [PubMed] 133. G. Stagni, D. O’Donnel, Y. J. Liu, DL Kellog Jr, T. Morgan, and A. M. M. Shepherd. Intradermal microdialysis: kinetics of iontophoretically delivered propanolol in forearm dermis. J. Control Release63:331–339 (2000). [PubMed] 134. G. Stagni, M. Ehsan Ali, and D. Weng. Pharmacokinetics of acyclovir in rabbit skin after i.v.-bolus, ointment, and iontophoretic administrations. Int. J. Pharm. 274:201–211 (2004). [PubMed] 135. C. J. Morgan, A. G. Renwick, and P. S. Friedmann. The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis. Br. J. Derm.148:434–443 (2003). [PubMed] 136. L. Groth, A. Jorgensen, and J. Serup. Cutaneous microdialysis in the rat: insertion trauma and effect of anaesthesia studied by laser Doppler perfusion imaging and histamine release. Skin Pharmacol. Appl. Skin Physiol.11:12–132 (1998). [PubMed] 137. L. Groth, and J. Serup. Cutaneous microdialysis in man: effects of needle insertion trauma and anaesthesia on skin perfusion, erythema and skin thickness. Acta Derm. Venereol.78:5–9 (1998). [PubMed] 138. F.-X. Mathy, A.-R. Denet, B. Vroman, P. Clarijs, A. Barel, R.K. Verbeeck, and V. Préat. In vivo tolerance assessment of skin after insertion of subcutaneous and cutaneous microdialysis probes in the rat. Skin Pharmacol. Appl. Skin Physiol. 16:18–27 (2003). [PubMed] 139. C. Anderson, T. Andersson, and K. Wardell. Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging. J. Invest. Dermatol.102:807–811 (1994). [PubMed] 140. L. J. Petersen, P. S. Skov, C. Bindslev-Jensen, and J. Sondergaard. Histamine release in immediate-type hypersensitivity reactions in intact human skin measured by microdialysis. A preliminary study. Allergy47:635–637 (1992). [PubMed] 141. L. J. Petersen. Measurement of histamine release in intact human skin by microdialysis technique, clinical and experimental findings. Danish Med. Bull.45:383–401 (1998). [PubMed]
142. J. A. Stenken. Methods and issues in microdialysis calibration. Anal. Chim. Acta.379:337–358 (1999).
143. A. L. Krogstad, P. A. Jansson, P. Gisslen, and P. Lonnroth. Microdialysis methodology for the measurement of dermal interstitial fluid in humans. Br. J. Dermatol.134:1005–1012 (1996). [PubMed] 144. S. Menacherry, W. Hubert, and J. B. Justice. In vivo calibration of microdialysis probes for exogenous compounds. Anal. Chem.64:577–583 (1992). [PubMed] 145. L. Stahle, S. Segersvard, and U. Ungerstedt. A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis. J. Pharmacol. Meth.25:41–52 (1991). [PubMed] 146. C. I. Larsson. The use of an “internal standard” for control of the recovery in microdialysis. Life Sci.49:PL73–PL78 (1991). [PubMed] 147. D. Scheller, and J. Kolb. The internal reference technique in microdialysis: a practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialyzate samples. J. Neurosci. Methods40:31–38 (1991). [PubMed] 148. C. Carneheim, and L. Staahle. Microdialysis of lipophilic compounds: a methodological study. Pharmacol. Toxicol.69:378–380 (1991). [PubMed] 149. Y. Kurosaki, S. Nakamura, Y. Shiojiri, and H. Kawasaki. Lipo-microdialysis: a new microdialysis method for studying the pharmacokinetics of lipophilic substances. Biol. Pharm. Bull.21:194–196 (1998). [PubMed] 150. M. I. Davies, J. D. Cooper, S. S. Desmond, C. E. Lunte, and S. Lunte. Analytical considerations for microdialysis sampling. Adv. Drug Deliv. Rev.45:169–188 (2000). [PubMed] 151. I. Tegeder, L. Brautigam, M. Podda, S. Meier, R. Kaufmann, G. Geisslinger, and M. Grundmann-Kollmann. Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen. Clin. Pharmacol. Ther.71:153–161 (2002). [PubMed] 152. C. Schrolnberger, M. Brunner, B. X. Mayer, H. G. Eichler, and M. Müller. Application of the minimal trauma tissue biopsy to transdermal clinical pharmacokinetric studies. J. Control Release75:297–306 (2001). [PubMed] 153. G. Volden, A. K. Thorsrud, I. Bjornson, and E. Jellum. Biochemical composition of suction blister fluid determined by high resolution multicomponent analysis (capillary gas chromatography—mass spectrometry and two-dimensional electrophoresis). J. Invest. Dermatol.75:421–424 (1980). [PubMed] 154. P. Svedman, and C. Svedman. Skin mini-erosion sampling technique: feasibility study with regard to serial glucose measurement. Pharm. Res.15:883–888 (1998). [PubMed] 155. S. Makki, P. Treffel, P. Humbert, and P. Agache. High performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans. J. Chromatogr.563:407–413 (1991). [PubMed] 156. P. Treffel, S. Makki, B. Faivre, P. Humbert, D. Blanc, and P. Agache. Citropten and bergapten suction blister fluid concentrations after solar product application in man. Skin Pharmacol.4:100–108 (1991). [PubMed] 157. C. Surber, K. P. Wilhelm, D. Bermann, and H. I. Maibach. In vivo skin penetration of acitretin in volunteers using three sampling techniques. Pharm. Res.10:1291–1294 (1993). [PubMed] 158. R. J. Scheuplein. Mechanism of percutaneous absorption II: Transient diffusion and the relative importance of various routes of skin penetration. J. Invest. Dermatol.48:79–88 (1967). [PubMed] 159. A. Rolland, N. Wagner, A. Chatelus, B. Shroot, and H. Schaefer. Site-specific drug delivery to pilosebaceous structures using polymeric microspheres. Pharm. Res.10:1738–1744 (1993). [PubMed] 160. R. A. Bojar, A. G. Cutclife, L. Graupe, W. J. Cunliffe, and K. T. Holland. Follicular concentrations of azelaic acid after a single topical application. Br. J. Dermatol.129:399–402 (1993). [PubMed] 161. OH Mills Jr, and A. M. Kligman. A human model for assaying comedolytic substances. Br. J. Derm.107:543–548 (1982). [PubMed]
162. N. Otberg, H. Richter, A. Knuttel, H. Schaefer, W. Sterry, and J. Lademann. Laser spectroscopic methods for the characterization of open and closed follicles. Laser Phys. Lett.1:46–49 (2004).
163. P. J. Caspers, G. W. Lucassen, E. A. Carter, H. A. Bruining, and G. J. Puppels. In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles. J. Invest. Dermatol.116:434–442 (2001). [PubMed] 164. L. Chrit, P. Bastien, B. Biatry, J. T. Simonnet, A. Potter, A. M. Minondo, F. Flament, R. Bazin, G. D. Sockalingum, F. Leroy, M. Manfait, and C. Hadjur. In vitro and in vivo confocal Raman study of human skin hydration: assessment of a new moisturizing agent, pMPC. Biopolymers.85:359–369 (2007). [PubMed] 165. L. Chrit, P. Bastien, G. D. Sockalingum, D. Batisse, F. Leroy, M. Manfait, and C. Hadjur. An in vivo randomized study of human skin moisturization by a new confocal Raman fiber-optic microprobe: assessment of a glycerol-based hydration cream. Skin Pharmacol. Physiol.19:207–215 (2006). [PubMed] 166. V. Wascotte, P. Caspers, J. de Sterke, M. Jadoul, R. H. Guy, and V. Préat. Assessment of the “skin reservoir” of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo. Pharm. Res, in press (2007). [PubMed]