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J Gen Physiol. Nov 1, 1962; 46(2): 297–313.
PMCID: PMC2195257
The Effects of Mechanical Stimulation on Some Electrical Properties of Axons
Fred J. Julian and David E. Goldman
From the Biophysics Division, Naval Medical Research Institute, Bethesda
Received July 16, 1962
Abstract
Rapid, short duration mechanical compression of lobster giant axons by a crystal-driven stylus produces a depolarization and an increase in membrane conductance which develop immediately with compression but take several seconds to recover. The conductance increase occurs even when the depolarization is prevented electrically. If sodium is removed from the external medium or if procaine is added to it, compression produces almost no depolarization. Small bundles of myelinated frog fibers are depolarized by rapid compression but recover very rapidly (milliseconds); "off" responses are occasionally seen. The results are discussed in terms of the mechanoelectric transducer behavior of an axon membrane.
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