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J Exp Med. 1987 November 1; 166(5): 1573–1578.
PMCID: PMC2189656

Inhibition of suppressor T lymphocytes by murine interferon beta


We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Fisher MS, Kripke ML. Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice. Science. 1982 Jun 4;216(4550):1133–1134. [PubMed]
  • Berendt MJ, North RJ. T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med. 1980 Jan 1;151(1):69–80. [PMC free article] [PubMed]
  • Dye ES, North RJ. T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases. J Exp Med. 1981 Oct 1;154(4):1033–1042. [PMC free article] [PubMed]
  • Sy MS, Miller SD, Claman HN. Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide. J Immunol. 1977 Jul;119(1):240–244. [PubMed]
  • Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME. Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med. 1979 Oct 1;150(4):761–776. [PMC free article] [PubMed]
  • Sahasrabudhe DM, McCune CS, O'Donnell RW, Henshaw EC. Inhibition of suppressor T lymphocytes (Ts) by cimetidine. J Immunol. 1987 May 1;138(9):2760–2763. [PubMed]
  • Dye ES, North RJ. Adoptive immunization against an established tumor with cytolytic versus memory T cells. Immediate versus delayed onset of regression. Transplantation. 1984 Jun;37(6):600–605. [PubMed]
  • Knop J, Stremmer R, Taborski U, Freitag W, de Maeyer-Guignard J, Macher E. Inhibition of the T suppressor circuit of delayed-type hypersensitivity by interferon. J Immunol. 1984 Nov;133(5):2412–2416. [PubMed]
  • Claman HN, Miller SD, Conlon PJ, Moorhead JW. Control of experimental contact sensitivity. Adv Immunol. 1980;30:121–157. [PubMed]
  • Kimchi A, Shure H, Revel M. Regulation of lymphocyte mitogenesis by (2'--5') oligo-isoadenylate. Nature. 1979 Dec 20;282(5741):849–851. [PubMed]

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