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J Exp Med. 1989 May 1; 169(5): 1557–1564.
PMCID: PMC2189325

Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain

Abstract

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Miller RA, Maloney DG, Warnke R, Levy R. Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med. 1982 Mar 4;306(9):517–522. [PubMed]
  • Meeker TC, Lowder J, Maloney DG, Miller RA, Thielemans K, Warnke R, Levy R. A clinical trial of anti-idiotype therapy for B cell malignancy. Blood. 1985 Jun;65(6):1349–1363. [PubMed]
  • Smith SD, Wood GW, Fried P, Lowman JT. In vitro growth of lymphoma colonies from children with non-Hodgkin's lymphoma. Cancer. 1981 Dec 15;48(12):2612–2623. [PubMed]
  • Clayberger C, Wright A, Medeiros LJ, Koller TD, Link MP, Smith SD, Warnke RA, Krensky AM. Absence of cell surface LFA-1 as a mechanism of escape from immunosurveillance. Lancet. 1987 Sep 5;2(8558):533–536. [PubMed]
  • Clayberger C, Holmes N, Wang PL, Koller TD, Parham P, Krensky AM. Determinants recognized by human cytotoxic T cells on a natural hybrid class I HLA molecule. J Exp Med. 1985 Nov 1;162(5):1709–1714. [PMC free article] [PubMed]
  • Koller TD, Clayberger C, Maryanski JL, Krensky AM. Human allospecific cytolytic T lymphocyte lysis of a murine cell transfected with HLA-A2. J Immunol. 1987 Apr 1;138(7):2044–2049. [PubMed]
  • Krensky AM, Clayberger C, Reiss CS, Strominger JL, Burakoff SJ. Specificity of OKT4+ cytotoxic T lymphocyte clones. J Immunol. 1982 Nov;129(5):2001–2003. [PubMed]
  • Krensky AM, Sanchez-Madrid F, Robbins E, Nagy JA, Springer TA, Burakoff SJ. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J Immunol. 1983 Aug;131(2):611–616. [PubMed]
  • Parham P, Bodmer WF. Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2. Nature. 1978 Nov 23;276(5686):397–399. [PubMed]
  • Krensky AM, Clayberger C, Greenstein JL, Crimmins M, Burakoff SJ. A DC-specific cytolytic T lymphocyte line is OKT8+1. J Immunol. 1983 Dec;131(6):2777–2780. [PubMed]
  • Spits H, Borst J, Tax W, Capel PJ, Terhorst C, de Vries JE. Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen. J Immunol. 1985 Sep;135(3):1922–1928. [PubMed]
  • Thielemans K, Maloney DG, Meeker T, Fujimoto J, Doss C, Warnke RA, Bindl J, Gralow J, Miller RA, Levy R. Strategies for production of monoclonal anti-idiotype antibodies against human B cell lymphomas. J Immunol. 1984 Jul;133(1):495–501. [PubMed]
  • Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS. Identification of a putative second T-cell receptor. Nature. 1986 Jul 10;322(6075):145–149. [PubMed]
  • Borst J, van de Griend RJ, van Oostveen JW, Ang SL, Melief CJ, Seidman JG, Bolhuis RL. A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes. Nature. 1987 Feb 19;325(6106):683–688. [PubMed]
  • Moingeon P, Jitsukawa S, Faure F, Troalen F, Triebel F, Graziani M, Forestier F, Bellet D, Bohuon C, Hercend T. A gamma-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity. Nature. 1987 Feb 19;325(6106):723–726. [PubMed]
  • Raulet DH, Garman RD, Saito H, Tonegawa S. Developmental regulation of T-cell receptor gene expression. Nature. 1985 Mar 7;314(6006):103–107. [PubMed]
  • Snodgrass HR, Dembić Z, Steinmetz M, von Boehmer H. Expression of T-cell antigen receptor genes during fetal development in the thymus. Nature. 1985 May 16;315(6016):232–233. [PubMed]
  • Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. Science. 1986 Dec 12;234(4782):1401–1405. [PubMed]
  • Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature. 309(5971):757–762. [PubMed]
  • Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J Exp Med. 1987 Apr 1;165(4):1076–1094. [PMC free article] [PubMed]
  • Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 1986 Jul 10;322(6075):179–181. [PubMed]
  • Weiss A, Newton M, Crommie D. Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6998–7002. [PubMed]
  • Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, Krangel MS. Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. Nature. 1987 Feb 19;325(6106):689–694. [PubMed]
  • Ciccone E, Viale O, Bottino C, Pende D, Migone N, Casorati G, Tambussi G, Moretta A, Moretta L. Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture. J Exp Med. 1988 Apr 1;167(4):1517–1522. [PMC free article] [PubMed]
  • Matis LA, Cron R, Bluestone JA. Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes. Nature. 1987 Nov 19;330(6145):262–264. [PubMed]

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