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J Exp Med. 1982 December 1; 156(6): 1755–1766.
PMCID: PMC2186870

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets

Abstract

The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that express early markers of melanocyte differentiation. A rudimentary surface antigen map of cells undergoing melanocyte differentiation and a new classification of melanomas based on the expression of melanocyte differentiation antigens are proposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Koprowski H, Steplewski Z, Herlyn D, Herlyn M. Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3405–3409. [PubMed]
  • Yeh MY, Hellström I, Brown JP, Warner GA, Hansen JA, Hellström KE. Cell surface antigens of human melanoma identified by monoclonal antibody. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2927–2931. [PubMed]
  • Dippold WG, Lloyd KO, Li LT, Ikeda H, Oettgen HF, Old LJ. Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies. Proc Natl Acad Sci U S A. 1980 Oct;77(10):6114–6118. [PubMed]
  • Carrel S, Accolla RS, Carmagnola AL, Mach JP. Common human melanoma-associated antigen(s) detected by monoclonal antibodies. Cancer Res. 1980 Jul;40(7):2523–2528. [PubMed]
  • Eisinger M, Marko O. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc Natl Acad Sci U S A. 1982 Mar;79(6):2018–2022. [PubMed]
  • Carey TE, Takahashi T, Resnick LA, Oettgen HF, Old LJ. Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells. Proc Natl Acad Sci U S A. 1976 Sep;73(9):3278–3282. [PubMed]
  • Pfreundschuh M, Shiku H, Takahashi T, Ueda R, Ransohoff J, Oettgen HF, Old LJ. Serological analysis of cell surface antigens of malignant human brain tumors. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5122–5126. [PubMed]
  • Ueda R, Ogata S, Morrissey DM, Finstad CL, Szkudlarek J, Whitmore WF, Oettgen HF, Lloyd KO, Old LJ. Cell surface antigens of human renal cancer defined by mouse monoclonal antibodies: identification of tissue-specific kidney glycoproteins. Proc Natl Acad Sci U S A. 1981 Aug;78(8):5122–5126. [PubMed]
  • Cairncross JG, Mattes MJ, Beresford HR, Albino AP, Houghton AN, Lloyd KO, Old LJ. Cell surface antigens of human astrocytoma defined by mouse monoclonal antibodies: identification of astrocytoma subsets. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5641–5645. [PubMed]
  • Lloyd KO, Ng J, Dippold WG. Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines. J Immunol. 1981 Jun;126(6):2408–2413. [PubMed]
  • Houghton AN, Taormina MC, Ikeda H, Watanabe T, Oettgen HF, Old LJ. Serological survey of normal humans for natural antibody to cell surface antigens of melanoma. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4260–4264. [PubMed]
  • Pomerantz SH. The tyrosine hydroxylase activity of mammalian tyrosinase. J Biol Chem. 1966 Jan 10;241(1):161–168. [PubMed]
  • OLD LJ, BOYSE EA. ANTIGENIC PROPERTIES OF EXPERIMENTAL LEUKEMIAS. I. SEROLOGICAL STUDIES IN VITRO WITH SPONTANEOUS AND RADIATION-INDUCED LEUKEMIAS. J Natl Cancer Inst. 1963 Oct;31:977–995. [PubMed]
  • REIF AE, ALLEN JM. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. [PMC free article] [PubMed]
  • Boyse EA, Miyazawa M, Aoki T, Old LJ. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. [PubMed]
  • Chu A, Eisinger M, Lee JS, Takezaki S, Kung PC, Edelson RL. Immunoelectron microscopic identification of Langerhans cells using a new antigenic marker. J Invest Dermatol. 1982 Feb;78(2):177–180. [PubMed]
  • Albino AP, Lloyd KO, Houghton AN, Oettgen HF, Old LJ. Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens. J Exp Med. 1981 Dec 1;154(6):1764–1778. [PMC free article] [PubMed]

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