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J Bacteriol. 1978 October; 136(1): 423–428.
PMCID: PMC218675

Bacteriophage Mu-induced modification of DNA is dependent upon a host function.

Abstract

The DNA of bacteriophage Mu, extracted from induced lysates, is partially resistant to digestion by the endonuclease BalI. This modification of DNA is controlled by the Mu modification function (mom), which acts in conjunction with the dam (DNA-adenine methylation) function of Escherichia coli. Since the BalI recognition site is apparently different from the dam recognition site, these results imply that either the specificity of the dam function is changed by the mom function or the mom function requires the dam function for its activity.

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Selected References

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  • Abelson J, Boram W, Bukhari AI, Faelen M, Howe M, Metlay M, Taylor AL, Toussaint A, Van de Putte P, Westmaas GC, et al. Summary of the genetic mapping of prophage Mu. Virology. 1973 Jul;54(1):90–92. [PubMed]
  • Allet B, Bukhari AI. Analysis of bacteriophage mu and lambda-mu hybrid DNAs by specific endonucleases. J Mol Biol. 1975 Mar 15;92(4):529–540. [PubMed]
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  • Toussaint A. The DNA modification function of temperate phage Mu-1. Virology. 1976 Mar;70(1):17–27. [PubMed]
  • Toussaint A. DNA modification of bacteriophage Mu-1 requires both host and bacteriophage functions. J Virol. 1977 Sep;23(3):825–826. [PMC free article] [PubMed]

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