PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jexpmedHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
 
J Exp Med. 1979 May 1; 149(5): 1183–1196.
PMCID: PMC2184859

Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6

Abstract

Flow microfluorometry was used to assess levels of xenotropic murine leukemia virus envelope-related cell-surface antigens (XenCSA) expressed on lymphocytes of mice derived from crosses between C57BL/6 (B6) and DBA/2 (D2); 24 recombinant inbred strains (BXD RIs) and 62 backcross mice were studied. The results suggest that XenCSA expression is affected by more than one gene but that the predominant influence is exerted by a single semidominant gene apparently located on chromosome 4 at or in close proximity to the Fv-1 locus. Studies of spontaneous virus production in B6D2F1 X D2 mice suggest that this locus may also affect production by spleen cells of xenotropic MuLV registering in a fluorescent antibody assay of mink lung cells.

Full Text

The Full Text of this article is available as a PDF (945K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Taylor BA, Heiniger HJ, Meier H. Genetic analysis of resistance to cadmium-induced testicular damage in mice. Proc Soc Exp Biol Med. 1973 Jul;143(3):629–633. [PubMed]
  • Taylor BA, Bailey DW, Cherry M, Riblet R, Weigert M. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644–646. [PubMed]
  • Womack JE, Lynes MA, Taylor BA. Genetic variation of an intestinal leucine arylaminopeptidase (Lap-1) in the mouse and its location on chromosome 9. Biochem Genet. 1975 Oct;13(9-10):511–518. [PubMed]
  • Taylor BA, Bedigian HG, Meier H. Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines. J Virol. 1977 Jul;23(1):106–109. [PMC free article] [PubMed]
  • Rowe WP, Pugh WE, Hartley JW. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. [PubMed]
  • Peebles PT. An in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus C, and the feline--primate viruses RD-114/CCC/M-7. Virology. 1975 Sep;67(1):288–291. [PubMed]
  • Henderson IC, Lieber MM, Todaro GJ. Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses. Virology. 1974 Jul;60(1):282–287. [PubMed]
  • Hartley JW, Rowe WP. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology. 1975 May;65(1):128–134. [PubMed]
  • Kawashima K, Ikeda H, Hartley JW, Stockert E, Rowe WP, Old LJ. Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680–4684. [PubMed]
  • Rowe WP, Sato H. Genetic mapping of the Fv-1 lcous of the mouse. Science. 1973 May 11;180(4086):640–641. [PubMed]
  • Haldane JB, Waddington CH. Inbreeding and Linkage. Genetics. 1931 Jul;16(4):357–374. [PubMed]
  • Kozak C, Rowe WP. Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains. Science. 1978 Mar 31;199(4336):1448–1449. [PubMed]
  • Eicher EM, Stern RH, Womack JE, Davisson MT, Roderick TH, Reynolds SC. Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651–660. [PubMed]
  • Ikeda H, Stockert E, Rowe WP, Boyse EA, Lilly F, Sato H, Jacobs S, Old LJ. Relation of chromosome 4 (linkage group 8) to murine leukemia virus-associated antigens of AKR mice. J Exp Med. 1973 Apr 1;137(4):1103–1107. [PMC free article] [PubMed]
  • Stockert E, Boyse EA, Sato H, Itakura K. Heredity of the GIX thymocyte antigen associated with murine leukemia virus: segregation data simulating genetic linkage. Proc Natl Acad Sci U S A. 1976 Jun;73(6):2077–2081. [PubMed]
  • Boyse EA. The Gx system in relation to C-type viruses and heredity. Immunol Rev. 1977 Jan;33:125–145. [PubMed]
  • Stockert E, Old LJ, Boyse EA. The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med. 1971 Jun 1;133(6):1334–1355. [PMC free article] [PubMed]
  • Ikeda H, Rowe WP, Boyse EA, Stockert E, Sato H, Jacobs S. Relationship of infectious murine leukemia virus and virus-related antigens in genetic crosses between AKR and the Fv-1 compatible strain C57L. J Exp Med. 1976 Jan 1;143(1):32–46. [PMC free article] [PubMed]
  • Obata Y, Stockert E, Boyse EA, Tung JS, Litman GW. Spontaneous autoimmunization to GIX cell surface antigen in hybrid mice. J Exp Med. 1976 Aug 1;144(2):533–542. [PMC free article] [PubMed]
  • Datta SK, Schwartz RS. Genetics of expression of xenotropic virus and autoimmunity in NZB mice. Nature. 1976 Sep 30;263(5576):412–415. [PubMed]
  • Datta SK, Schwartz RS. Mendelian segregation of loci controlling xenotropic virus production in NZB crosses. Virology. 1977 Dec;83(2):449–452. [PubMed]
  • Hartley JW, Wolford NK, Old LJ, Rowe WP. A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789–792. [PubMed]
  • Elder JH, Gautsch JW, Jensen FC, Lerner RA, Hartley JW, Rowe WP. Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4676–4680. [PubMed]
  • Levy JA. Autoimmunity and neoplasia. The possible role of C-type viruses. Am J Clin Pathol. 1974 Aug;62(2):258–280. [PubMed]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press