Search tips
Search criteria 


Logo of jbacterPermissionsJournals.ASM.orgJournalJB ArticleJournal InfoAuthorsReviewers
J Bacteriol. 1979 September; 139(3): 1068–1071.
PMCID: PMC218059

Extrachromosomal psi+ determinant suppresses nonsense mutations in yeast.


The extrachromosomal psi+ determinant in the yeast Saccharomyces cerevisiae enhanced the expression of Mendelian UAA suppressors by 6- to 10-fold. The psi+ determinant by itself is a weak UAA suppressor that caused the production of approximately 1% of the normal level of iso-1-cytochrome c in a strain containing the UAA mutation cycl-72.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (426K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Culbertson MR, Charnas L, Johnson MT, Fink GR. Frameshifts and frameshift suppressors in Saccharomyces cerevisiae. Genetics. 1977 Aug;86(4):745–764. [PubMed]
  • Downie JA, Stewart JW, Brockman N, Schweingruber AM, Sherman F. Structural gene for yeast iso-2-cytochrome c. J Mol Biol. 1977 Jun 25;113(2):369–384. [PubMed]
  • Sherman F, Stewart JW. Genetics and biosynthesis of cytochrome c. Annu Rev Genet. 1971;5:257–296. [PubMed]
  • Sherman F, Taber H, Campbell W. Genetic determination of iso-cytochromes c in yeast. J Mol Biol. 1965 Aug;13(1):21–39. [PubMed]
  • Stewart JW, Sherman F. Demonstration of UAG as a nonsense codon in bakers' yeast by amino-acid replacements in iso-1-cytochrome c. J Mol Biol. 1972 Jul 28;68(3):429–443. [PubMed]
  • Stewart JW, Sherman F, Shipman NA, Jackson M. Identification and mutational relocation of the AUG codon initiating translation of iso-1-cytochrome c in yeast. J Biol Chem. 1971 Dec 25;246(24):7429–7445. [PubMed]
  • Young CS, Cox BS. Extrachromosomal elements in a super-suppression system of yeast. II. Relations with other extrachromosomal elements. Heredity (Edinb) 1972 Apr;28(2):189–199. [PubMed]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)