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Schizencephaly is a rare disorder of brain development
resulting in the formation of abnormal unilateral or bilateral clefts in the cerebral hemispheres. It is often accompanied by partial seizures, mental retardation, and hemiparesis. Two patients are described with clear psychotic symptoms with either unilateral or
bilateral schizencephaly. The implications of the association between
schizencephaly and psychosis in these patients for understanding the
biology of the psychoses are discussed.