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Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
J R Coll Gen Pract. 1979 October; 29(207): 602, 604-606.
PMCID: PMC2159305

The treatment of hypertension with propranolol and bendrofluazide


In 101 hypertensive patients, the effects of a combination of propranolol and bendrofluazide were compared with those of each drug alone. After an introductory period with a placebo, the patients received, in a double-blind randomized trial, propranolol 80 mg twice a day, bendrofluazide 2.5 mg twice a day, or both drugs together twice daily. The combination produced significantly greater reductions in lying, standing, and post-exercise systolic and diastolic blood pressure than either drug separately. Side-effects were minimal and the combination was well accepted by patients.

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Selected References

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  • Berglund G, Andersson O, Larsson O, Wilhelmsen L. Antihypertensive effect and side-effects of bendroflumethiazide and propranolol. Acta Med Scand. 1976;199(6):499–506. [PubMed]
  • Galloway DB, Glover SC, Hendry WG, Logie AW, Petrie JC, Smith MC, Lewis JA, Simpson WT. Propranolol in hypertension: a dose-response study. Br Med J. 1976 Jul 17;2(6028):140–142. [PMC free article] [PubMed]
  • Mitchell I, Lodge R, Lawson AA. Adjuvant effect of bendrofluazide on propranolol in hypertension. Scott Med J. 1972 Oct;17(10):326–329. [PubMed]
  • Petrie JC, Galloway DB, Webster J, Simpson WT, Lewis JA. Atenolol and bendrofluazide in hypertension. Br Med J. 1975 Oct 18;4(5989):133–135. [PMC free article] [PubMed]
  • Prichard BN, Gillam PM. Treatment of hypertension with propranolol. Br Med J. 1969 Jan 4;1(5635):7–16. [PMC free article] [PubMed]
  • Zacharias FJ, Cowen KJ, Prestt J, Vickers J, Wall BG. Propranolol in hypertension: a study of long-term therapy, 1964-1970. Am Heart J. 1972 Jun;83(6):755–761. [PubMed]

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