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Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
J R Coll Gen Pract. 1979 July; 29(204): 413, 415-416.
PMCID: PMC2159226

A randomized controlled trial of aspirin in the prevention of early mortality in myocardial infarction


A randomized controlled trial is reported in which a single dose of aspirin (300 mg) was given to patients with myocardial infarction on first contact with a general practitioner. A total of 1,705 patients with confirmed infarction were studied, and survival ascertained. There was no evidence of benefit from the aspirin.

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Selected References

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  • Elwood PC, Cochrane AL, Burr ML, Sweetnam PM, Williams G, Welsby E, Hughes SJ, Renton R. A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J. 1974 Mar 9;1(5905):436–440. [PMC free article] [PubMed]
  • Haerem JW. Platelet aggregates and mural microthrombi in the early stages of acute, fatal coronary disease. Thromb Res. 1974 Aug;5(2):243–249. [PubMed]
  • Hughes A, Tonks RS. Lung and heart lesions from intravascular platelet clumping and its sequelae. J Pathol Bacteriol. 1968 Apr;95(2):523–526. [PubMed]
  • Moncada S, Vane JR. Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull. 1978 May;34(2):129–135. [PubMed]
  • Rowan RM, McDonald GA, Renton RL, Corne SJ, Brown DF. Inhibition of platelet release reaction by acetylsalicylic acid. Postgrad Med J. 1976 Feb;52(604):71–75. [PMC free article] [PubMed]
  • Stuart RK. Platelet function studies in human beings receiving 300 mg. of aspirin per day. J Lab Clin Med. 1970 Mar;75(3):463–471. [PubMed]
  • Verstraete M. Are agents affecting platelet functions clinically useful? Am J Med. 1976 Dec;61(6):897–914. [PubMed]
  • Warren JV. Editorial: A revolution in coronary artery disease. J Chronic Dis. 1973 Sep;26(9):547–551. [PubMed]

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