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Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
 
J R Coll Gen Pract. 1978 October; 28(195): 587–590.
PMCID: PMC2158890

Double blind trial of clonidine in the treatment of migraine in a general practice

Abstract

The value of clonidine (`Dixarit') for the prophylaxis of migraine has been assessed by a double blind cross-over trial. A dose of up to 0·15 mg daily was used. No effect on the frequency of the headaches could be detected over and above the 60 per cent reduction observed with a placebo. Severity, assessed subjectively by the patient, when it varied between placebo and clonidine, was less with clonidine (p<0·01). There was also some evidence that headaches lasting more than 12 hours were less common during treatment with the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Blau JN. Migraine--research. Br Med J. 1971 Jun 26;2(5764):751–754. [PMC free article] [PubMed]
  • Ryan RE, Sr, Diamond S, Ryan RE., Jr Double blind study of clonidine and placebo for the prophylactic treatment of migraine. Headache. 1975 Oct;15(3):202–210. [PubMed]
  • Shafar J, Tallett ER, Knowlson PA. Evaluation of clonidine in prophylaxis of migraine. Double-blind trial and follow-up. Lancet. 1972 Feb 19;1(7747):403–407. [PubMed]
  • Wall MC, Wilkinson M. Clonidine against migraine. Lancet. 1973 Sep 1;2(7827):510–510. [PubMed]
  • Wilkinson M. Clonidine for migraine. Lancet. 1969 Aug 23;2(7617):430–430. [PubMed]
  • Zaimis E, Hanington E. A possible pharmacological approach to migraine. Lancet. 1969 Aug 9;2(7615):298–300. [PubMed]

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