Search tips
Search criteria 


Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
J R Coll Gen Pract. 1978 October; 28(195): 587–590.
PMCID: PMC2158890

Double blind trial of clonidine in the treatment of migraine in a general practice


The value of clonidine (`Dixarit') for the prophylaxis of migraine has been assessed by a double blind cross-over trial. A dose of up to 0·15 mg daily was used. No effect on the frequency of the headaches could be detected over and above the 60 per cent reduction observed with a placebo. Severity, assessed subjectively by the patient, when it varied between placebo and clonidine, was less with clonidine (p<0·01). There was also some evidence that headaches lasting more than 12 hours were less common during treatment with the drug.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (675K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Blau JN. Migraine--research. Br Med J. 1971 Jun 26;2(5764):751–754. [PMC free article] [PubMed]
  • Ryan RE, Sr, Diamond S, Ryan RE., Jr Double blind study of clonidine and placebo for the prophylactic treatment of migraine. Headache. 1975 Oct;15(3):202–210. [PubMed]
  • Shafar J, Tallett ER, Knowlson PA. Evaluation of clonidine in prophylaxis of migraine. Double-blind trial and follow-up. Lancet. 1972 Feb 19;1(7747):403–407. [PubMed]
  • Wall MC, Wilkinson M. Clonidine against migraine. Lancet. 1973 Sep 1;2(7827):510–510. [PubMed]
  • Wilkinson M. Clonidine for migraine. Lancet. 1969 Aug 23;2(7617):430–430. [PubMed]
  • Zaimis E, Hanington E. A possible pharmacological approach to migraine. Lancet. 1969 Aug 9;2(7615):298–300. [PubMed]

Articles from The Journal of the Royal College of General Practitioners are provided here courtesy of Royal College of General Practitioners