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Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
J R Coll Gen Pract. 1976 August; 26(169): 591–594.
PMCID: PMC2158317

Night medication in rheumatoid arthritis


The efficacy of indomethacin 100 mg, diazepam 10 mg, and placebo in producing sleep, relieving night pain, and reducing the severity of morning stiffness, was compared in 18 patients in hospital with active classical or definite rheumatoid arthritis.

There was no statistically significant difference in the preference of patients or sleep score among the three forms of treatment. Both indomethacin and diazepam were more effective than placebo in relieving night pain. Indomethacin decreased, but diazepam increased, morning stiffness in comparison to placebo. Neither active therapy produced significant side-effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Huskisson EC, Hart FD. The use of indomethacin and aloxiprin at night. Practitioner. 1972 Feb;208(244):248–251. [PubMed]
  • Huskisson EC, Taylor RT, Burston D, Chuter PJ, Hart FD. Evening indomethacin in the treatment of rheumatoid arthritis. Ann Rheum Dis. 1970 Jul;29(4):393–396. [PMC free article] [PubMed]
  • DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed]
  • Wolff BB. Evaluation of hypnotics in outpatients with insomnia using a questionnaire and a self-rating technique. Clin Pharmacol Ther. 1974 Feb;15(2):130–140. [PubMed]

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