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J R Coll Gen Pract. 1976 March; 26(164): 228–230.
PMCID: PMC2158056

Folate supplements during pregnancy

Abstract

In a controlled, prospective trial, the effects of giving ferrous sulphate 50 mg daily to 76 pregnant women was compared with giving ferrous sulphate 50 mg daily plus folic acid 0·5 mg daily to 82 women in 12 general practices in South-east England.

No differences in obstetric complications were found between the two groups, although the evidence of some of the listed complications may be too rare for detection in a sample of patients of this size.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CHANARIN I, ROTHMAN D, BERRY V. IRON DEFICIENCY AND ITS RELATION TO FOLIC-ACID STATUS IN PREGNANCY: RESULTS OF A CLINICAL TRIAL. Br Med J. 1965 Feb 20;1(5433):480–485. [PMC free article] [PubMed]
  • Fletcher J, Gurr A, Fellingham FR, Prankerd TA, Brant HA, Menzies DN. The value of folic acid supplements in pregnancy. J Obstet Gynaecol Br Commonw. 1971 Sep;78(9):781–785. [PubMed]
  • Hoffbrand AV, Newcombe FA, Mollin DL. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol. 1966 Jan;19(1):17–28. [PMC free article] [PubMed]
  • Rae PG, Robb PM. Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels. J Clin Pathol. 1970 Jul;23(5):379–391. [PMC free article] [PubMed]
  • SCOTT JM. Therapy in the megaloblastic anaemias of pregnancy. J Obstet Gynaecol Br Emp. 1954 Oct;61(5):646–651. [PubMed]
  • Streiff RR, Little AB. Folic acid deficiency in pregnancy. N Engl J Med. 1967 Apr 6;276(14):776–779. [PubMed]
  • Thambu J, Llewellyn-Jones D. Bone marrow studies in abruptio placentae. J Obstet Gynaecol Br Commonw. 1966 Dec;73(6):930–933. [PubMed]
  • YOUNG DS, HICKS JM. METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON. J Clin Pathol. 1965 Jan;18:98–102. [PMC free article] [PubMed]

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