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Anesth Prog. 1994; 41(3): 81–82.
PMCID: PMC2148817

Propofol for sedation in a mentally retarded dental patient.


A 21-yr-old mentally retarded and cardiovascularly compromised woman who required dental restorative work and extractions was admitted to our clinic. We had previously successfully sedated her with propofol and midazolam. In this case she was sedated with a 1% propofol solution administered initially at a rate of 8 mg/kg-hr. After 5 min, the infusion rate was lowered to 5 mg/kg-hr, and after the local anesthetic injection, was adjusted to 3 mg/kg-hr. After 15 min, the patient became restless, and the propofol infusion rate was again increased to 5 mg/kg-hr. The patient's airway was well maintained during the entire procedure; she remained well sedated, and no adverse effects were experienced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bennett CR. Conscious sedation: an alternative to general anesthesia. J Dent Res. 1984 Jun;63(6):832–833. [PubMed]
  • Valtonen M, Salonen M, Forssell H, Scheinin M, Viinamäki O. Propofol infusion for sedation in outpatient oral surgery. A comparison with diazepam. Anaesthesia. 1989 Sep;44(9):730–734. [PubMed]
  • van der Bijl P, Roelofse JA. Propofol and midazolam for conscious sedation in a mentally retarded dental patient. Anesth Prog. 1992;39(1-2):36–37. [PMC free article] [PubMed]
  • Mackenzie N, Grant IS. Propofol for intravenous sedation. Anaesthesia. 1987 Jan;42(1):3–6. [PubMed]
  • Adam HK, Kay B, Douglas EJ. Blood disoprofol levels in anesthetised patients. Correlation of concentrations after single or repeated doses with hypnotic activity. Anaesthesia. 1982 May;37(5):536–540. [PubMed]

Articles from Anesthesia Progress are provided here courtesy of American Dental Society of Anesthesiology