J Exp Med. 1971 January 31; 133(2): 275–288. | PMCID: PMC2138906 |
Copyright © 1971 by The Rockefeller University Press
ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Judah Folkman, Ezio Merler, Charles Abernathy, and Gretchen Williams
From the Departments of Surgery and Pediatrics, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115
Received September 15, 1970
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.
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