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J Hyg (Lond). 1972 September; 70(3): 445–453.
PMCID: PMC2130208

Rabies vaccines and interferon

Abstract

Samples of Fermi, Semple, modified Semple, Duck embryo and tissue culture rabies vaccine were inoculated by different routes and in different doses into rabbits, mice and hamsters. The vaccines induced neither detectable interferon nor immediate protection against lethal challenge with CVS rabies virus.

Under similar conditions, high but transient levels of interferon were induced in control animals of the same species with the polynucleotide complex Poly I.C. Hamsters but not mice were protected by Poly I.C.-induced interferon.

No autointerference by vaccine with challenge virus was established. Vaccine-induced protection in mice was directly related to immune response.

Full text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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