Search tips
Search criteria 


Logo of jexpmedHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
J Exp Med. 1909 September 2; 11(5): 673–685.
PMCID: PMC2124734



1. We have confirmed previous work which shows that the injection of bile increases the tone of the vagus nerve, and that this action can be abolished after the administration of atropine. 2. We have found that the amount of bile salts in a lethal dose of pig's bile for dog's will, if inejcted alone, produce neither a fall in blood pressure nor a slowing in rate. 3. We have found that the amount of pigment in a lethal dose of the bile will, if injected alone, cause death with slowing of the heart and lowering of blood pressure. 4. We have found that the bile pigment in combination with calcium or sodium is less toxic than uncombined pigment. 5. We have found that in experimentally produced jaundice the calcium content of the blood is increased, while that of the liver, muscle and brain are decreased. 6. We are of the opinion that increase in calcium in the blood is a protective mechanism against the circulating pigments of obstructive jaundice.

Full Text

The Full Text of this article is available as a PDF (577K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Meltzer SJ, Salant W. STUDIES ON THE TOXICITY OF BILE : I. THE EFFECTS OF INTRAVENOUS INJECTIONS OF BILE UPON BLOOD PRESSURE. J Exp Med. 1905 Jun 10;7(3):280–291. [PMC free article] [PubMed]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press