Resistance of cardiomyocytes from wild-type and transgenic mice to hypoxia. A) Epifluorescent images of Fura-2-loaded cardiomyocytes exposed to hypoxia. ×40. Time course of Fura-2 ratio (A1) and cell diameters (A2) corresponding to experiments in panel A. B) Average survival time of wild-type and transgenic cardiomyocytes exposed to hypoxia. Bars represent mean ± se (n=17–18). *P < 0.01. C) Percentage of cells from wild-type or transgenic mice that died/survived, n = 17–18. *P < 0.01. Note that cardiomyocytes from transgenic mice are more resistant to hypoxia then cardiomyocytes from wild-type mice.