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J Exp Med. 1992 October 1; 176(4): 1203–1207.
PMCID: PMC2119400

Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response

Abstract

Our earlier reports demonstrated that Cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (SIV), fixed SIV-infected C8166 (a human T lymphoblastoid cell line) cells, or fixed uninfected C8166 cells can be protected against a challenge infection with the 32H isolate of SIVmac 251 (grown in C8166) (Stott, E. J., W. L. Chan, K. H. G. Mills, M. Page, F. Taffs, M. Cranage, P. Greenway, and P. Kitchin. 1990. Lancet. 336:1538; Stott, E. J., P. A. Kitchin, M. Page, B. Flanagan, L. F. Taffs, W. L. Chan, K. H. G. Mills, P. Silvera, and A. Rodgers. 1991. Nature [Lond.]. 353:393). Protection is correlated with the levels of antibody response to cellular antigens in the human cells from which the virus immunogen was grown. However, the mechanism of protection is unclear. We report here the analysis of sera from these protected monkeys and demonstrate that there is positive correlation of protection with antibody response to the HLA class I molecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Desrosiers RC, Wyand MS, Kodama T, Ringler DJ, Arthur LO, Sehgal PK, Letvin NL, King NW, Daniel MD. Vaccine protection against simian immunodeficiency virus infection. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6353–6357. [PubMed]
  • Murphey-Corb M, Martin LN, Davison-Fairburn B, Montelaro RC, Miller M, West M, Ohkawa S, Baskin GB, Zhang JY, Putney SD, et al. A formalin-inactivated whole SIV vaccine confers protection in macaques. Science. 1989 Dec 8;246(4935):1293–1297. [PubMed]
  • Carlson JR, McGraw TP, Keddie E, Yee JL, Rosenthal A, Langlois AJ, Dickover R, Donovan R, Luciw PA, Jennings MB, et al. Vaccine protection of rhesus macaques against simian immunodeficiency virus infection. AIDS Res Hum Retroviruses. 1990 Nov;6(11):1239–1246. [PubMed]
  • Stott EJ, Chan WL, Mills KH, Page M, Taffs F, Cranage M, Greenaway P, Kitchin P. Preliminary report: protection of cynomolgus macaques against simian immunodeficiency virus by fixed infected-cell vaccine. Lancet. 1990 Dec 22;336(8730):1538–1541. [PubMed]
  • Langlois AJ, Weinhold KJ, Matthews TJ, Greenberg ML, Bolognesi DP. The ability of certain SIV vaccines to provoke reactions against normal cells. Science. 1992 Jan 17;255(5042):292–293. [PubMed]
  • Le Grand R, Vaslin B, Vogt G, Roques P, Humbert M, Dormont D. AIDS vaccine developments. Nature. 1992 Feb 20;355(6362):684–684. [PubMed]
  • Osterhaus A, de Vries P, Heeney J. AIDS vaccine developments. Nature. 1992 Feb 20;355(6362):684–685. [PubMed]
  • Cranage MP, Ashworth LA, Greenaway PJ, Murphey-Corb M, Desrosiers RC. AIDS vaccine developments. Nature. 1992 Feb 20;355(6362):685–686. [PubMed]
  • Kitchin PA, Almond N, Szotyori Z, Fromholc CE, McAlpine L, Silvera P, Stott EJ, Cranage M, Baskerville A, Schild G. The use of the polymerase chain reaction for the detection of Simian immunodeficiency virus in experimentally infected macaques. J Virol Methods. 1990 Apr;28(1):85–99. [PubMed]
  • Chan WL, Lukig ML, Liew FY. Helper T cells induced by an immunopurified herpes simplex virus type I (HSV-I) 115 kilodalton glycoprotein (gB) protect mice against HSV-I infection. J Exp Med. 1985 Oct 1;162(4):1304–1318. [PMC free article] [PubMed]
  • McGrath M, Witte O, Pincus T, Weissman IL. Retrovirus purification: method that conserves envelope glycoprotein and maximizes infectivity. J Virol. 1978 Mar;25(3):923–927. [PMC free article] [PubMed]
  • LaThangue NB, Shriver K, Dawson C, Chan WL. Herpes simplex virus infection causes the accumulation of a heat-shock protein. EMBO J. 1984 Feb;3(2):267–277. [PubMed]
  • Henderson LE, Sowder R, Copeland TD, Oroszlan S, Arthur LO, Robey WG, Fischinger PJ. Direct identification of class II histocompatibility DR proteins in preparations of human T-cell lymphotropic virus type III. J Virol. 1987 Feb;61(2):629–632. [PMC free article] [PubMed]
  • Putkonen P, Thorstensson R, Ghavamzadeh L, Albert J, Hild K, Biberfeld G, Norrby E. Prevention of HIV-2 and SIVsm infection by passive immunization in cynomolgus monkeys. Nature. 1991 Aug 1;352(6334):436–438. [PubMed]
  • Hu SL, Abrams K, Barber GN, Moran P, Zarling JM, Langlois AJ, Kuller L, Morton WR, Benveniste RE. Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160. Science. 1992 Jan 24;255(5043):456–459. [PubMed]
  • Maddox J. AIDS research turned upside down. Nature. 1991 Sep 26;353(6342):297–297. [PubMed]

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