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Thorax. 2007 August; 62(8): 742–743.
PMCID: PMC2117293

Spirometric screening for COPD: wishful thinking, not evidence

The effect of spirometric screening on smoking cessation rates in the before and after study reported by Bednarek and colleagues1 is interpreted by the authors and, with reservations, in the accompanying editorial by Mannino2 as evidence to support the introduction of spirometric screening to detect early chronic obstructive pulmonary disease (COPD). This goes against the evidence of the study itself, and opposes the results of the comparative study of spirometric screening published by the same workers in 2004.3 Bednarek et al show an effect of spirometric screening in smokers with moderate or severe COPD (using 1995 European Respiratory Society criteria), but no effect in mild COPD despite the large numbers in their study. They repeat the findings of their earlier study, which is not mentioned in this paper by the authors themselves, nor is it mentioned by Mannino in his editorial. What is going on? Is there any significance in the fact that this work comes out of a programme entitled National Program of Early Detection and Prevention of COPD?4 What seems to be clear from this work is that there is no evidence that early detection leads to prevention in COPD.

In the first study Gorecka et al3 also claimed that their findings supported spirometric screening in mild disease. In fact they showed no effect overall, found evidence of an effect in a subgroup analysis of subjects with moderate or severe obstructive lung disease, and went on to make claims for the role of screening: “All smokers irrespective of their lung function tried to modify the habit as the result of screening for COPD combined with smoking cessation advice. The diagnosis of AL (airway limitation) motivated smokers to quit smoking.” Yet the results state unequivocally that there was no difference between smokers who had airflow limitation diagnosed and those who had normal lung function (NLF): “The one year cessation rate in smokers with AL was 10.8% versus 8.4% in smokers with NLF (NS).”

Why are these findings being interpreted over‐optimistically as evidence of the value of screening for mild COPD? The most likely reason is wishful thinking, since the evidence suggests the opposite conclusion to that supported in the editorial by Mannino. Perhaps it simply arises from the frustrating recognition that COPD is common in adults but is predominantly undiagnosed.

There is a serious consequence from promoting early detection of COPD if there is no evidence that it makes any difference. Putting resources into spirometry for the early detection of COPD draws resources from more effective work, the most compelling of which in this context is general smoking cessation. In the study by Bednarek et al,1 71 people needed to be screened for every additional 1 year smoking quit achieved. This is equivalent to a cost of about €650 per additional smoking quitter.

Smoking cessation is the most important intervention in the primary and secondary prevention of COPD. It is equally important in the primary and secondary prevention of cardiovascular disease and many cancers including lung cancer. Until there is some definite advantage to be gained from the early detection of COPD in improving cessation rates among smokers, there is no justification for promoting spirometric screening for mild COPD as a separate public health strategy. On current evidence, screening to detect mild COPD is not warranted and will waste resources that would be better employed to promote smoking cessation in general.

References

1. Bednarek M, Gorecka D, Wielgomas J. et al Smokers with airway obstruction are more likely to quit smoking. Thorax 2006. 61869–873.873 [PMC free article] [PubMed]
2. Mannino D M. Spirometric screening: does it work? Thorax 2006. 61834–835.835 [PMC free article] [PubMed]
3. Gorecka D, Bednarek M, Nowinski A. et al Diagnosis of airflow limitation combined with smoking cessation advice increases stop‐smoking rate. Chest 2003. 1231916–1923.1923 [PubMed]
4. Zielinski J, Bednarek M, Gorecka D. [National Program of Early Detection and Prevention of COPD in the years 2000–2002]. Pneumonol Alergol Pol 2005. 73116–121.121 [PubMed]

Articles from Thorax are provided here courtesy of BMJ Group