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Thorax. Jan 2006; 61(1): 86–88.
PMCID: PMC2080699
Convergence of the epidemiology and pathology of COPD
J Vestbo and J C Hogg
J Vestbo, Department of Cardiology and Respiratory Medicine, Hvidovre University Hospital, Hvidovre, Denmark; and North West Lung Centre, South Manchester University Hospital Trust, Manchester, UK
J C Hogg, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul's Hospital, Vancouver, Canada
Correspondence to: Professor J Vestbo
Department of Cardiology and Respiratory Medicine, Hvidovre University Hospital, Kettegaard Alle 30, DK‐2650 Hvidovre, Denmark; joergen. vestbo@hh.hosp.dk
Received May 4, 2005; Accepted September 21, 2005.
The epidemiology of chronic obstructive pulmonary disease (COPD) has been dominated by one hypothesis stating that cigarette smoking and chronic bronchitis were the key to pathogenesis and another that asthma, chronic bronchitis, and even emphysema are related to different expressions of a primary airway abnormality. The first hypothesis was rejected in the late 1960s based on a longitudinal study of working men where only a fraction of smokers developed COPD and where development of COPD was independent of the absence or presence of chronic bronchitis. Chronic bronchitis in more advanced COPD was subsequently associated with a more rapid decline in lung function and more frequent exacerbations. The second hypothesis is more difficult to test but longitudinal studies have shown that the presence of bronchial hyperresponsiveness may predict the subjects who go on to develop COPD. This brief review attempts to reconcile these findings with the pathology found in the lung.
Keywords: chronic obstructive pulmonary disease, pathology, epidemiology, smoking, pathogenesis
The major risk factor for the development of chronic obstructive pulmonary disease (COPD) is the inhalation of toxic gases and particles that are primarily—but not exclusively—generated in tobacco smoke.1,2 A renewed interest in the natural history of this condition has been stimulated by the recognition of its growing contribution to time lost from work as well as morbidity and mortality throughout the world.3
By the 1950s the tobacco smoking habit was known to be associated with chronic cough and sputum production, and that smokers who developed chronic bronchitis had impaired lung defences that resulted in colonisation and infection of the lower airways.4 Post mortem examination of the lung suggested that the excess sputum production that defined chronic bronchitis was associated with a hypersecretion of mucus from enlarged bronchial glands and pathological studies suggested a rough relationship between the presence of chronic bronchitis and emphysema.5 A concept that subsequently became known as “The British hypothesis” proposed that smoking caused mucus hypersecretion and impaired host defences leading to chronic infection, disseminated bronchiolar obstruction, and emphysema. In epidemiology, the presence of chronic mucus hypersecretion is based on responses to the validated British Medical Council questionnaire on cough and phlegm,6,7 with the inherent weakness that any mucus that is not expectorated will not be registered as phlegm. Nevertheless, Fletcher and associates set out to test the British hypothesis in a seminal epidemiological study of working men from West London conducted from 1961 to 1969 and summarised in an important monograph in 1976.8 In appendix E of that monograph the authors state that: “It was not until 1967 that we realised that a considerable proportion of men with airflow obstruction had no evidence of mucus hypersecretion and could not, by the Medical Research Council definition, be considered to have obstructive bronchitis.” Based on these findings, the authors offered the alternative explanation that “emphysema and intrinsic disease of the small airways were involved to different degrees in these obstructed men”.
The data of Fletcher et al showed that the symptoms of chronic mucus hypersecretion in the absence of airflow limitation—now classified as COPD GOLD stage 0—was a benign condition that did not progress to COPD, and the Copenhagen City Heart Study9 confirmed this observation. In this study the odds ratio for developing COPD after 5 and 15 years when comparing the presence and absence of chronic mucus hypersecretion was 1.1 (0.9–1.4) and 1.2 (0.9–1.6), respectively, after adjusting for age, sex and smoking. However, the Copenhagen database10 also showed that mucus hypersecretion was associated with a decline in forced expiratory volume in 1 second (FEV1) when subjects with more advanced COPD were included. The effect was seen in both men and women and was stronger for chronic mucus hypersecretion than for occasional phlegm. A recent report on the pathology of small airway obstruction in COPD11 suggests that a shift from an innate to an adaptive immune response in severe (GOLD 3) and very severe (GOLD 4) COPD might contribute to this change by driving the inflammatory/remodelling process and increasing fixed airway obstruction at this stage of the disease. Furthermore, other reports have shown that the later stages of COPD are associated with an increased frequency of lower respiratory tract infections12 and with chronic sputum production and an accelerated decline in FEV1.13,14 Both bacterial and viral infection can cause exacerbations,15,16 bacterial colonisation has been related to a decline in FEV1,17 and Banerjee et al postulated that the decline in FEV1 resulted from a chronic low grade inflammatory response to the presence of bacteria.18 These results are consistent with the hypothesis that inhaled toxic gases and particles damage the lung's innate defence system in the early stages of the disease by reducing mucociliary clearance, producing an ineffective cough, disrupting the epithelial barrier, and initiating an acute on chronic inflammatory process in the distal lung. Although the microbial colonisation and/or repeat infections that are common in the later stages of the disease probably account for most of the adaptive immune response in GOLD stages 3 and 4, it has been argued that this response might also be attributed to autoimmune disease.19,20 New knowledge about the nature of the signals that link the innate and/or adaptive immune response to the repair and remodelling process would be helpful as multivariate analysis of the pathology data suggests that thickening of walls and restriction of the lumen of the small airways were most strongly associated with airflow limitation.11
Fletcher et al used the term “mucus hypersecretion” rather than chronic bronchitis because the pathologists working at that time were unable to define an association between bronchial inflammation and gland enlargement in the post mortem specimens they studied, possibly because of the interference of preterminal events associated with death. However, subsequent studies of lung tissue removed at surgery21,22 showed that excess sputum production was associated with a chronic inflammatory process that involved the epithelial lining of the airway lumen, glands, and gland ducts of the central airways of these patients. Moreover, these studies also showed that the lesions in the central airways in chronic bronchitis were independent of the presence of airflow limitation.21 Collectively, these pathological features of the disease fit with the epidemiology reported from both London and Copenhagen showing that chronic bronchitis is a benign disease early in the course of COPD (GOLD 0–1), presumably because the innate host defences remain more or less intact, whereas the same symptoms are ominous in the later stages of the disease (GOLD 3–4) when the airways become colonised and infected. Recent studies have found that subjects with chronic mucus hypersecretion have an increased use of health care,23 and in the NHANES dataset they had a small excess overall mortality of borderline statistical significance.24 We do not think, however, that this implies a role for chronic mucus hypersecretion in the early stages of COPD.
Fletcher et al tried to assess the contribution of emphysema to airflow limitation based on plain chest radiographs obtained from 568 of the men in their study. However, they gave it up when it became apparent that observations based on an agreed grading system for the radiological assessment of emphysema severity could not be reproduced by two eminent radiologists who examined the films independently on two separate occasions (appendix D).6 This left the diagnosis and quantification of emphysema in the hands of pathologists willing to take a quantitative approach to the study of the post mortem lungs until the introduction of computed tomographic (CT) scanning. These post mortem studies established that approximately 40% of smokers have some emphysema in their lungs when they die, and that this ranged from 15% in the third decade to a peak of 60% in the seventh and falling back to 50% in the ninth decade.25 They also showed that the volume of total lung taken up by emphysema was 0–70% in smokers and 0–40% in non‐smokers. Subsequent studies of surgically resected specimens have shown that substantial amounts of emphysema can be present in patients with normal lung function,26 but the relevance of this early emphysema to the natural history of COPD needs to be clarified. Although CT scanning27 and MRI imaging of hyperpolarised gas28 have provided much more sensitive and specific imaging tools to assess emphysema, they have not been used in studies of the natural history of COPD. One CT based clinical trial has assessed the effect of replacement therapy on the progression of the emphysema in α1‐antitrypsin deficiency,29 but the cost of the scans, the fairly widespread disagreement about the precise boundary that separates fully expanded normal lung from early emphysema, and the radiation dose required for repeated scans in longitudinal studies remain problematical.
The importance of small airway obstruction to airflow limitation in COPD was first suggested by an influential report by Macklem and Mead in 196730 which showed that the smaller airways (<2 mm internal diameter) account for only 10–15% of the total resistance to airflow in the normal canine lung. This was subsequently confirmed in both post mortem human lungs31 and in living patients,32 and although another group33 disputed the finding of very low peripheral resistance in the normal lung, all three agreed that the major site of resistance in COPD is in the smaller conducting airways. Mead34 suggested that these airways represented a “quiet zone” in the normal lung where considerable disease might be present before airflow limitation would be discovered using standard tests of pulmonary function. An intense period of investigation followed, based on the hypothesis that early detection and treatment of peripheral airway disease would prevent progression. However, the results were unhelpful because the tobacco smoking habit causes some degree of peripheral lung inflammation and abnormal small airway function in everyone and only a small number actually progress to full blown COPD.35 Therefore, like the symptoms of chronic bronchitis, tests for small airways disease fell out of favour because they could not predict which smokers with normal lung function would go on to develop severe COPD.
A different hypothesis was put forward by a group from Groningen led by Professor Orie who introduced the term “chronic non‐specific lung disease” in 1961.36 Their approach, termed the “The Dutch hypothesis”, introduced the concept that the airways obstruction associated with asthma, chronic bronchitis, and even emphysema is related to different expressions of a primary abnormality in the airways. The precise nature of this abnormality is difficult to define, but the idea that different disease phenotypes might result from a variation in the host response to the toxic gases and particles present in tobacco smoke is attractive because it could explain why only a fraction of smokers of the same age and sex who have smoked equivalent amounts develop COPD. Pathology based studies provided some support for this hypothesis by showing an amplified inflammatory immune response in the small airways11 and lung parenchyma37 of smokers with late stage (GOLD 3 and 4) COPD compared to those with similar smoking histories who maintain normal lung function. In both Dutch epidemiological studies38,39 and the NIH sponsored Lung Health Study40 bronchial hyperresponsiveness was the most important predictor of further decline in lung function, and it has also been shown to be a predictor of vital prognosis.41 The problem is that it is difficult to know if hyperresponsiveness initiates the early disease or if early disease initiates the changes that cause airway hyperresponsiveness. None of the mechanisms put forward to explain hyperresponsiveness are easy to investigate and the hypothesis is still regarded as controversial. Nevertheless, smokers with self‐reported asthma have a more rapid decline in FEV1 than smokers without asthma, pointing to features of asthma being a predictor of susceptibility.42 However, when carefully examined, there are significant differences in both the physiology and airways cytology between patients with fixed airflow obstruction derived from chronic asthma and patients with “classical” COPD.43 Nevertheless, the Dutch hypothesis resonates with the concept that COPD is a complex genetic abnormality in which products of certain genes or groups of genes interact with environmental stimuli to produce an excessive response that results in disease. The identification of a disease marker capable of predicting the type of response to the inhalation of toxic gases and particles that results in COPD could lead to more precise studies of the natural history and response to treatment of COPD patients.44
Studies of epidemiology and pathology have clearly shown that, when maximum expiratory flow is normal (GOLD 0), the symptoms of chronic bronchitis do not increase the risk for progression to the more severe stages of COPD. However, the presence of these same symptoms in persons who have reached the severe (GOLD 3) and very severe (GOLD 4) stages of COPD predict both a more rapid decline in lung function and more frequent acute exacerbations of COPD. Studies from several sources indicate that the innate defence system of the lungs is damaged early in the course of COPD, and that this damage to the innate system is associated with colonisation and infection of the lower airways in GOLD stages 3 and 4 where histological evidence of a sharp increase in the adaptive immune response appears. The association between bronchial hyperresponsiveness and the appearance of airflow limitation serves as a marker for the later appearance of airflow limitation, possibly because it reflects remodelling of the peripheral airways. Tests that are easier to perform than bronchial responsiveness that could provide a precise estimate of the risk for developing COPD would clearly be helpful. Perhaps the current genetic approach to the study of COPD will provide markers to identify the 15–20% of smokers who will progress to severe disease as well as the means to prevent this inexorable progression.
Footnotes
Competing interests: none.
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