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Br J Cancer. 1996 December; 74(12): 2003–2007.
PMCID: PMC2074811

Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.

Abstract

Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies against AMF-R (gp78) were used to stain 221 primary gastric cancer specimens, and level of expression was examined in relation to pathological stage and prognostic values. In 125 out of 221 (56.6%) patients, gp78 was detected. Expression of gp78 was associated with macroscopic type, lymphatic and venous invasions, and lymph node and peritoneal metastasis. The level of gp78 expression in the cancer specimens was associated with histopathological stage and grade of tumour penetration. Positive gp78 expression was significantly associated with poor prognosis (P < 0.001). This significant relationship remained among patients in stage II and III. The results suggest that gp78 expression could be used as a prognostic marker in gastric cancer patients.

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Selected References

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  • Adachi Y, Kamakura T, Mori M, Maehara Y, Sugimachi K. Role of lymph node dissection and splenectomy in node-positive gastric carcinoma. Surgery. 1994 Nov;116(5):837–841. [PubMed]
  • de Aretxabala X, Konishi K, Yonemura Y, Ueno K, Yagi M, Noguchi M, Miwa K, Miyazaki I. Node dissection in gastric cancer. Br J Surg. 1987 Sep;74(9):770–773. [PubMed]
  • Baba H, Maehara Y, Takeuchi H, Inutsuka S, Okuyama T, Adachi Y, Akazawa K, Sugimachi K. Effect of lymph node dissection on the prognosis in patients with node-negative early gastric cancer. Surgery. 1995 Feb;117(2):165–169. [PubMed]
  • Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res. 1990 Oct 1;50(19):6130–6138. [PubMed]
  • Fujimura T, Yonemura Y, Fushida S, Urade M, Takegawa S, Kamata T, Sugiyama K, Hasegawa H, Katayama K, Miwa K, et al. Continuous hyperthermic peritoneal perfusion for the treatment of peritoneal dissemination in gastric cancers and subsequent second-look operation. Cancer. 1990 Jan 1;65(1):65–71. [PubMed]
  • Hallissey MT, Dunn JA, Ward LC, Allum WH. The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. Lancet. 1994 May 28;343(8909):1309–1312. [PubMed]
  • Hart IR, Goode NT, Wilson RE. Molecular aspects of the metastatic cascade. Biochim Biophys Acta. 1989 Jul 28;989(1):65–84. [PubMed]
  • Liotta LA, Mandler R, Murano G, Katz DA, Gordon RK, Chiang PK, Schiffmann E. Tumor cell autocrine motility factor. Proc Natl Acad Sci U S A. 1986 May;83(10):3302–3306. [PubMed]
  • Maehara Y, Okuyama T, Oshiro T, Baba H, Adachi Y, Sugimachi K. Analysis of 390 patients surviving 10 years or longer after curative resection for gastric cancer. Oncology. 1994 Jul-Aug;51(4):366–371. [PubMed]
  • Maruyama K, Watanabe H, Shiozaki H, Takayama T, Gofuku J, Yano H, Inoue M, Tamura S, Raz A, Monden M. Expression of autocrine motility factor receptor in human esophageal squamous cell carcinoma. Int J Cancer. 1995 Oct 20;64(5):316–321. [PubMed]
  • Mooradian DL, McCarthy JB, Komanduri KV, Furcht LT. Effects of transforming growth factor-beta 1 on human pulmonary adenocarcinoma cell adhesion, motility, and invasion in vitro. J Natl Cancer Inst. 1992 Apr 1;84(7):523–527. [PubMed]
  • Nabi IR, Watanabe H, Raz A. Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res. 1990 Jan 15;50(2):409–414. [PubMed]
  • Nabi IR, Watanabe H, Silletti S, Raz A. Tumor cell autocrine motility factor receptor. EXS. 1991;59:163–177. [PubMed]
  • Nabi IR, Watanabe H, Raz A. Autocrine motility factor and its receptor: role in cell locomotion and metastasis. Cancer Metastasis Rev. 1992 Mar;11(1):5–20. [PubMed]
  • Nakamori S, Watanabe H, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Raz A. Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence. Cancer. 1994 Oct 1;74(7):1855–1862. [PubMed]
  • Nakazato H, Koike A, Saji S, Ogawa N, Sakamoto J. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet. 1994 May 7;343(8906):1122–1126. [PubMed]
  • Nekarda H, Schmitt M, Ulm K, Wenninger A, Vogelsang H, Becker K, Roder JD, Fink U, Siewert JR. Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer. Cancer Res. 1994 Jun 1;54(11):2900–2907. [PubMed]
  • Ninomiya I, Endo Y, Yonemura Y, Noguchi M, Fushida S, Nakai M, Takamura H, Harada F, Suzuki T, Miyazaki I, et al. Specific detection of c-erbB-2 mRNA expression in gastric cancers by the polymerase chain reaction following reverse transcription. Br J Cancer. 1992 Jul;66(1):84–87. [PMC free article] [PubMed]
  • Nomura H, Sato H, Seiki M, Mai M, Okada Y. Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res. 1995 Aug 1;55(15):3263–3266. [PubMed]
  • Otto T, Birchmeier W, Schmidt U, Hinke A, Schipper J, Rübben H, Raz A. Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res. 1994 Jun 15;54(12):3120–3123. [PubMed]
  • Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature. 1994 Jul 7;370(6484):61–65. [PubMed]
  • Sato Y, Rifkin DB. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol. 1988 Sep;107(3):1199–1205. [PMC free article] [PubMed]
  • Seppä H, Grotendorst G, Seppä S, Schiffmann E, Martin GR. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol. 1982 Feb;92(2):584–588. [PMC free article] [PubMed]
  • Silletti S, Raz A. Autocrine motility factor is a growth factor. Biochem Biophys Res Commun. 1993 Jul 15;194(1):446–457. [PubMed]
  • Silletti S, Watanabe H, Hogan V, Nabi IR, Raz A. Purification of B16-F1 melanoma autocrine motility factor and its receptor. Cancer Res. 1991 Jul 1;51(13):3507–3511. [PubMed]
  • Stracke ML, Engel JD, Wilson LW, Rechler MM, Liotta LA, Schiffmann E. The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells. J Biol Chem. 1989 Dec 25;264(36):21544–21549. [PubMed]
  • Stracke ML, Krutzsch HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, Liotta LA. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem. 1992 Feb 5;267(4):2524–2529. [PubMed]
  • Turley EA, Austen L, Vandeligt K, Clary C. Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells. J Cell Biol. 1991 Mar;112(5):1041–1047. [PMC free article] [PubMed]
  • Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A. Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem. 1991 Jul 15;266(20):13442–13448. [PubMed]
  • Watanabe H, Nabi IR, Raz A. The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. Cancer Res. 1991 May 15;51(10):2699–2705. [PubMed]
  • Watanabe H, Kanbe K, Chigira M. Differential purification of autocrine motility factor derived from a murine protein-free fibrosarcoma. Clin Exp Metastasis. 1994 Mar;12(2):155–163. [PubMed]
  • Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y, et al. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7001–7005. [PubMed]
  • Yonemura Y, Katayama K, Kamata T, Fushida S, Segawa M, Ooyama S, Miwa K, Miyazaki I. Surgical treatment of advanced gastric cancer with metastasis in para-aortic lymph node. Int Surg. 1991 Oct-Dec;76(4):222–225. [PubMed]
  • Yonemura Y, Ooyama S, Matumoto H, Kamata T, Kimura H, Takegawa S, Kosaka T, Yamaguchi A, Miwa K, Miyazaki I. Pancreaticoduodenectomy in combination with right hemicolectomy for surgical treatment of advanced gastric carcinoma located in the lower half of the stomach. Int Surg. 1991 Oct-Dec;76(4):226–229. [PubMed]

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