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Br J Cancer. 1996 September; 74(6): 961–963.
PMCID: PMC2074723

Paclitaxel for malignant pleural mesothelioma: a phase II study of the EORTC Lung Cancer Cooperative Group.

Abstract

The EORTC Lung Cancer Cooperative Group undertook a phase II study of paclitaxel in 25 chemotherapy-naive patients with malignant pleural mesothelioma. Paclitaxel was given intravenously at a dose of 200 mg m-2 as a 3 h infusion every 3 weeks, after standard premedication with corticosteroids and antihistamines. This regimen was well tolerated, with < 4% of cycles resulting in severe toxicity. No major objective responses were observed and ten patients had stable disease. Median survival time was 39 weeks and the 1 year survival rate was 30%. In conclusion, paclitaxel at the dose and schedule investigated in this trial had no major activity in the treatment of malignant pleural mesothelioma.

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Selected References

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  • Boutin C, Rey F, Gouvernet J, Viallat JR, Astoul P, Ledoray V. Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part 2: Prognosis and staging. Cancer. 1993 Jul 15;72(2):394–404. [PubMed]
  • van Breukelen FJ, Mattson K, Giaccone G, van Zandwijk N, Planteydt HT, Kirkpatrick A, Dalesio O. Mitoxantrone in malignant pleural mesothelioma: a study by the EORTC Lung Cancer Cooperative Group. Eur J Cancer. 1991;27(12):1627–1629. [PubMed]
  • Calavrezos A, Koschel G, Hüsselmann H, Taylessani A, Heilmann HP, Fabel H, Schmoll HJ, Dietrich H, Hain E. Malignant mesothelioma of the pleura. A prospective therapeutic study of 132 patients from 1981-1985. Klin Wochenschr. 1988 Jul 15;66(14):607–613. [PubMed]
  • Gupta RS. Taxol resistant mutants of Chinese hamster ovary cells: genetic biochemical, and cross-resistance studies. J Cell Physiol. 1983 Jan;114(1):137–144. [PubMed]
  • Krarup-Hansen A, Hansen HH. Chemotherapy in malignant mesothelioma: a review. Cancer Chemother Pharmacol. 1991;28(5):319–330. [PubMed]
  • Krarup-Hansen A. Phase II trials of malignant mesothelioma: a commentary and update. Lung Cancer. 1994 Sep;11(3-4):305–308. [PubMed]
  • Mattson K, Giaccone G, Kirkpatrick A, Evrard D, Tammilehto L, van Breukelen FJ, Planteydt HT, van Zandwijk N. Epirubicin in malignant mesothelioma: a phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol. 1992 May;10(5):824–828. [PubMed]
  • Van Meerbeeck JP. Prognostic factors in malignant mesothelioma: where do we go from here? Eur Respir J. 1994 Jun;7(6):1029–1031. [PubMed]
  • Pisani RJ, Colby TV, Williams DE. Malignant mesothelioma of the pleura. Mayo Clin Proc. 1988 Dec;63(12):1234–1244. [PubMed]
  • Rowinsky EK, Donehower RC. Paclitaxel (taxol) N Engl J Med. 1995 Apr 13;332(15):1004–1014. [PubMed]
  • Rowinsky EK, Eisenhauer EA, Chaudhry V, Arbuck SG, Donehower RC. Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol. 1993 Aug;20(4 Suppl 3):1–15. [PubMed]
  • Schiller JH, Storer B, Tutsch K, Arzoomanian R, Alberti D, Feierabend C, Spriggs D. Phase I trial of 3-hour infusion of paclitaxel with or without granulocyte colony-stimulating factor in patients with advanced cancer. J Clin Oncol. 1994 Feb;12(2):241–248. [PubMed]
  • Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials. 1989 Mar;10(1):1–10. [PubMed]
  • Vogelzang NJ. Malignant mesothelioma: diagnostic and management strategies for 1992. Semin Oncol. 1992 Aug;19(4 Suppl 11):64–71. [PubMed]

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