PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Arch Dis Child. 2007 June; 92(6): 539.
PMCID: PMC2066138

Red fingers syndrome and HIV infection

An 18 month old female, with a history of perinatally acquired HIV infection, treated with estavudine, lamivudine and ritonavir, was CDC immunological category 3 (T CD4+ lymphocytes: 467/μl), clinical category 3 and had a viral load log10 of 5.0. The child presented with painless erythematous lesions, which blanched under pressure, in the periungual and pulp areas of all fingers (fig 11).). Skin biopsy showed dilated blood vessels in the upper dermis; no inflammatory cells were detected. Hepatic function was normal and the patient tested serologically negative for hepatitis B and C.

figure ac113993.f1
Figure 1 Periungual erythema restricted to the distal parts of the fingers. Parental/guardian informed consent was obtained for publication of this figure.

Many mucocutaneous changes and specific skin diseases are associated with HIV infection.1,2,3 Distal finger and toe redness is termed red finger syndrome and has been described in adult patients with HIV.4,5 Some of these patients were co‐infected with hepatitis virus, mainly hepatitis C.5

Red finger syndrome is rare in children and consists of well‐delineated erythema of the periungual and pulp areas, with occasional telangiectasia, on the fingers and/or toes. The lesion is painless with at least a 1 month evolution and the nail plate is normal.5,6 Histopathological studies have produced non‐specific findings on an increased number of dilated blood vessels in the superficial dermis.5,7 The cause of this finger and toe redness remains unknown. Viral liver diseases and also the high viral load of HIV may play a role.8

Footnotes

Competing interests: None.

Parental/guardian informed consent was obtained for publication of the person's details in this report.

References

1. Wananukul S, Deekajorndech T, Panchareon C. et al Mucocutaneous findings in pediatric AIDS related to degree of immunosuppression. Pediatr Dermatol 2003. 20(4)289–294.294 [PubMed]
2. Stefanaki C, Stratigos A J, Stratigos J D. Skin manifestations of HIV‐1 infection in children. Clin Dermatol 2002. 20(1)74–86.86 [PubMed]
3. Smith K J, Skelton H G, Yeager J. et al Clinical features of inflammatory dermatoses in human immunodeficiency virus type 1 disease and their correlation with Walter Reed stage. Military Medical Consortium for Applied Retroviral Research. J Am Acad Dermatol 1993. 28(2 Pt 1)167–173.173 [PubMed]
4. Cribier B, Mena M L, Rey D. et al Nail changes in patients infected with human immunodeficiency virus. A prospective controlled study. Arch Dermatol 1998. 134(10)1216–1220.1220 [PubMed]
5. Pechere M, Krischer J, Rosay A. et al Red fingers syndrome in patients with HIV and hepatitis C infection. Lancet 1996. 348(9021)196–197.197 [PubMed]
6. Itin P H, Gilli L, Nuesch R. et al Erythema of the proximal nailfold in HIV‐infected patients. J Am Acad Dermatol 1996. 35(4)631–633.633 [PubMed]
7. Osaer F, Aubin F, Bresson‐Hadni S. et al Red fingers syndrome in a HIV‐negative woman with hepatitis C cirrhosis. Br J Dermatol 1998. 138(1)193–194.194 [PubMed]
8. Doutre M S, Bernard N, Beylot‐Barry M. et al Red fingers syndrome: acrosyndrome related to vascular growth endothelial factor? Clin Exp Dermatol 2001. 26219–220.220 [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group