Search tips
Search criteria 


Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child. 2007 June; 92(6): 561.
PMCID: PMC2066135

Clinical and laboratory profile of dengue, leptospirosis and malaria in children: a study from Mumbai

In Mumbai, India there is an increase in dengue, malaria and leptospirosis during the monsoon season.1 Children present with fever, vomiting and hypotension, which makes it difficult to identify the aetiology. Thus, we undertook a study over a period of 1 month from 15 July 2005 to 14 August 2005 to determine the clinical and laboratory features of these illnesses. Thirty two patients with fever, vomiting, diarrhoea, bleeding manifestations, hypotension, hepatomegaly, splenomegaly, jaundice and/or oliguria were registered as probable cases of dengue, leptospirosis or malaria. Diagnosis of dengue was based on a positive IgM capture ELISA test.2 Diagnosis of leptospirosis was made on a positive leptospira TRI‐DOT test and confirmed by a positive leptospira IgM ELISA test. Diagnosis of malaria was based on demonstration of malarial parasites on peripheral blood smear or a positive OptiMAL test. Data were compared using the χ2 test for proportions and analysis of variance (one way ANOVA) for continuous data.

Eleven patients (34.4%) tested positive for dengue IgM, nine patients (28.1%) tested positive for leptospirosis and seven patients (21.9%) tested positive for malaria. Four (57.1%) of the seven patients with malaria had vivax malaria, two (28.6%) had falciparum malaria and one (14.3%) had mixed falciparum and vivax malaria. Two patients (6.3%) grew Pseudomona aeruginosa on blood culture and two patients (6.3%) had dysentery and giardiasis. Co‐infection was seen in six (19%) patients. Patients with dengue had the highest packed cell volume (PCV), whereas patients with malaria had a low PCV. Patients with malaria had the lowest platelet count, patients with dengue had a platelet count of less than 100 000/mm3 and patients with leptospirosis had a near normal platelet count. Blood urea nitrogen (BUN) and creatinine were elevated in patients with leptospirosis. Elevated serum glutamic pyruvic transaminase (SGPT) and hepatomegaly was seen in dengue and splenomegaly was seen in malaria. Other clinical and laboratory features are depicted in table 11.

Table thumbnail
Table 1 Clinical and laboratory abnormalities in dengue, leptospirosis and malaria

To conclude, patients with dengue had haemoconcentration, thrombocytopenia, elevated SGPT and hepatomegaly as reported in previous studies.1,3 Anaemia and splenomegaly in a child with fever and thrombocytopenia was predictive of malaria. Interestingly, patients with leptospirosis presented with fever and non‐oliguric renal failure and near normal platelet count. Renal failure in patients with leptospirosis is due to tubulointerstitial renal failure.4,5,6 All our patients recovered with penicillin and thus renal biopsy was not carried out. Although, our patients recovered within 4–5 days, those with dengue and malaria required ionotropic support. In addition, patients with dengue also required fresh frozen plasma because of bleeding.


The authors thank Dr Dod, Chief Senior Executive, B.J. Wadia Hospital for Children for giving permission for the publication of this article.


Competing interests: None.


1. Shah I, Despande G C, Tardeja P N. Outbreak of dengue in Mumbai and predictive markers for dengue shock syndrome. J Trop Pediatr 2004. 50301–305.305 [PubMed]
2. Vaughn D W, Nisalak A, Solomon T. et al Rapid serologic diagnosis of dengue virus infection using a commercial capture ELISA that distinguishes primary and secondary infections. Am J Trop Med Hyg 1999. 60689–698.698
3. Shah I, Katira B. Clinical and laboratory abnormalities due to dengue in hospitalized children in Mumbai in 2004. Dengue Bulletin 2005. 2990–96.96
4. Celin B D, Harmankaya O, Hasman H. et al Acute renal failure: a common manifestation of leptospirosis. Ren Fail 2004. 26655–661.661 [PubMed]
5. Vochvanichsanong P, Dissanee Wate P, Mitarnun W. Tubulointerstitial renal failure in childhood leptospirosis. Pediatr Emerg Care 1999. 15332–334.334 [PubMed]
6. Marotto P C, Marotto M S, Santos D L. et al Outcome of leptospirosis in children. Am J Trop Med Hyg 1997. 56307–310.310 [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group