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J Bacteriol. 1993 September; 175(17): 5297–5300.
PMCID: PMC206581

Peptidyl transferase: protein, ribonucleoprotein, or RNA?

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Selected References

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  • Barta A, Kuechler E. Part of the 23S RNA located in the 11S RNA fragment is a constituent of the ribosomal peptidyltransferase centre. FEBS Lett. 1983 Nov 14;163(2):319–323. [PubMed]
  • Barta A, Steiner G, Brosius J, Noller HF, Kuechler E. Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3607–3611. [PubMed]
  • Bispink L, Matthaei H. Photoaffinity labeling of 23 S rRNA in Escherichia coli ribosomes with poly(U)-coded ethyl 2-diazomalonyl-Phe-tRNA. FEBS Lett. 1973 Dec 1;37(2):291–294. [PubMed]
  • Breitmeyer JB, Noller HF. Affinity labeling of specific regions of 23 S RNA by reaction of N-bromoacetyl-phenylalanyl-transfer RNA with Escherichia coli ribosomes. J Mol Biol. 1976 Mar 5;101(3):297–306. [PubMed]
  • Cech TR, Bass BL. Biological catalysis by RNA. Annu Rev Biochem. 1986;55:599–629. [PubMed]
  • Celma ML, Monro RE, Vazquez D. Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes. FEBS Lett. 1970 Feb 16;6(3):273–277. [PubMed]
  • Girshovich AS, Bochkareva ES, Kramarov VM, Ovchinnikov YuA E. coli 30 S and 50 S ribosomal subparticle components in the localization region of the tRNA acceptor terminus. FEBS Lett. 1974 Sep 1;45(1):213–217. [PubMed]
  • Hampl H, Schulze H, Nierhaus KH. Ribosomal components from Escherichia coli 50 S subunits involved in the reconstitution of peptidyltransferase activity. J Biol Chem. 1981 Mar 10;256(5):2284–2288. [PubMed]
  • Maden BE, Traut RR, Monro RE. Ribosome-catalysed peptidyl transfer: the polyphenylalanine system. J Mol Biol. 1968 Jul 28;35(2):333–345. [PubMed]
  • Moazed D, Noller HF. Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie. 1987 Aug;69(8):879–884. [PubMed]
  • Moazed D, Noller HF. Intermediate states in the movement of transfer RNA in the ribosome. Nature. 1989 Nov 9;342(6246):142–148. [PubMed]
  • Moazed D, Noller HF. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites. Cell. 1989 May 19;57(4):585–597. [PubMed]
  • Moazed D, Noller HF. Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3725–3728. [PubMed]
  • Moore VG, Atchison RE, Thomas G, Moran M, Noller HF. Identification of a ribosomal protein essential for peptidyl transferase activity. Proc Natl Acad Sci U S A. 1975 Mar;72(3):844–848. [PubMed]
  • Monro RE, Marcker KA. Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide. J Mol Biol. 1967 Apr 28;25(2):347–350. [PubMed]
  • Nierhaus KH, Montejo V. A protein involved in the peptidyltransferase activity of Escherichia coli ribosomes. Proc Natl Acad Sci U S A. 1973 Jul;70(7):1931–1935. [PubMed]
  • Noller HF, Hoffarth V, Zimniak L. Unusual resistance of peptidyl transferase to protein extraction procedures. Science. 1992 Jun 5;256(5062):1416–1419. [PubMed]
  • Smith D, Burgin AB, Haas ES, Pace NR. Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis. J Biol Chem. 1992 Feb 5;267(4):2429–2436. [PubMed]
  • Staehelin T, Maglott DM, Monro RE. On the catalytic center of peptidyl transfer: a part of the 50 S ribosome structure. Cold Spring Harb Symp Quant Biol. 1969;34:39–48. [PubMed]
  • Steiner G, Kuechler E, Barta A. Photo-affinity labelling at the peptidyl transferase centre reveals two different positions for the A- and P-sites in domain V of 23S rRNA. EMBO J. 1988 Dec 1;7(12):3949–3955. [PubMed]
  • Stiege W, Glotz C, Brimacombe R. Localisation of a series of intra-RNA cross-links in the secondary and tertiary structure of 23S RNA, induced by ultraviolet irradiation of Escherichia coli 50S ribosomal subunits. Nucleic Acids Res. 1983 Mar 25;11(6):1687–1706. [PMC free article] [PubMed]
  • Teraoka H, Nierhaus KH. Protein L16 induces a conformational change when incorporated into a L16-deficient core derived from Escherichia coli ribosomes. FEBS Lett. 1978 Apr 15;88(2):223–226. [PubMed]
  • Vester B, Garrett RA. The importance of highly conserved nucleotides in the binding region of chloramphenicol at the peptidyl transfer centre of Escherichia coli 23S ribosomal RNA. EMBO J. 1988 Nov;7(11):3577–3587. [PubMed]
  • Woese CR, Gutell RR. Evidence for several higher order structural elements in ribosomal RNA. Proc Natl Acad Sci U S A. 1989 May;86(9):3119–3122. [PubMed]
  • Wower J, Hixson SS, Zimmermann RA. Labeling the peptidyltransferase center of the Escherichia coli ribosome with photoreactive tRNA(Phe) derivatives containing azidoadenosine at the 3' end of the acceptor arm: a model of the tRNA-ribosome complex. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5232–5236. [PubMed]

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