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Br J Cancer. 1997; 75(3): 348–353.
PMCID: PMC2063366
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
M. Noguchi, M. Minami, R. Yagasaki, K. Kinoshita, M. Earashi, H. Kitagawa, T. Taniya, and I. Miyazaki
Operation Center, Kanazawa University Hospital, Takara-machi, Japan.
Abstract
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
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