PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
 
Br J Cancer. 1997; 75(4): 593–596.
PMCID: PMC2063298

Histopathology of breast cancer in relation to age.

Abstract

Histological reports of 1869 consecutive women with invasive breast cancer have been reviewed to determine whether histological features of the tumour's were related to the patients' age. The patients, treated between 1983 and 1992, were divided into four groups, based on age. There were 148 aged < or = 39 years, 355 aged 40-49 years, 984 aged 50-69 years and 382 aged 70 years or more. The most outstanding finding was the increase in incidence of grade III infiltrating ductal carcinoma in those aged < or = 39 years (P < 0.0001). Certain tumour types, in particular lobular, were reported more frequently in the oldest age group. Additionally, there was a significant reduction of axillary lymph node metastases, vascular invasion and lymphoplasmacytic stromal reaction with increasing age, all of which were independent of tumour grade. These data suggest that there may be age-related changes in the histology of breast cancer and, in some cases, less aggressive features in the elderly. However, as the life expectancy of women over the age of 70 may be many years, treatment should be based on histological prognostic features of the primary tumour rather than age alone.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (650K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Alderson MR, Hamlin I, Staunton MD. The relative significance of prognostic factors in breast carcinoma. Br J Cancer. 1971 Dec;25(4):646–656. [PMC free article] [PubMed]
  • Amsterdam E, Birkenfeld S, Gilad A, Krispin M. Surgery for carcinoma of the breast in women over 70 years of age. J Surg Oncol. 1987 Jul;35(3):180–183. [PubMed]
  • BLOOM HJ, RICHARDSON WW. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. [PMC free article] [PubMed]
  • Carter D, Orr SL, Merino MJ. Intracystic papillary carcinoma of the breast. After mastectomy, radiotherapy or excisional biopsy alone. Cancer. 1983 Jul 1;52(1):14–19. [PubMed]
  • Cutler SJ, Black MM, Mork T, Harvei S, Freeman C. Further observations on prognostic factors in cancer of the female breast. Cancer. 1969 Oct;24(4):653–667. [PubMed]
  • Dawson PJ, Ferguson DJ, Karrison T. The pathological findings of breast cancer in patients surviving 25 years after radical mastectomy. Cancer. 1982 Nov 15;50(10):2131–2138. [PubMed]
  • Elston CW, Gresham GA, Rao GS, Zebro T, Haybittle JL, Houghton J, Kearney G. The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects. Br J Cancer. 1982 May;45(5):655–669. [PMC free article] [PubMed]
  • Holmberg L, Lindgren A, Nordén T, Adami HO, Bergström R. Age as a determinant of axillary node involvement in invasive breast cancer. Acta Oncol. 1992;31(5):533–538. [PubMed]
  • Hunt KE, Fry DE, Bland KI. Breast carcinoma in the elderly patient: an assessment of operative risk, morbidity and mortality. Am J Surg. 1980 Sep;140(3):339–342. [PubMed]
  • White D, Jones DB, Cooke T, Kirkham N. Natural killer (NK) activity in peripheral blood lymphocytes of patients with benign and malignant breast disease. Br J Cancer. 1982 Oct;46(4):611–616. [PMC free article] [PubMed]
  • Lee CG, McCormick B, Mazumdar M, Vetto J, Borgen PI. Infiltrating breast carcinoma in patients age 30 years and younger: long term outcome for life, relapse, and second primary tumors. Int J Radiat Oncol Biol Phys. 1992;23(5):969–975. [PubMed]
  • Pinder SE, Ellis IO, Galea M, O'Rouke S, Blamey RW, Elston CW. Pathological prognostic factors in breast cancer. III. Vascular invasion: relationship with recurrence and survival in a large study with long-term follow-up. Histopathology. 1994 Jan;24(1):41–47. [PubMed]
  • de la Rochefordiere A, Asselain B, Campana F, Scholl SM, Fenton J, Vilcoq JR, Durand JC, Pouillart P, Magdelenat H, Fourquet A. Age as prognostic factor in premenopausal breast carcinoma. Lancet. 1993 Apr 24;341(8852):1039–1043. [PubMed]
  • Rosen PP, Saigo PE, Braun DW, Weathers E, Kinne DW. Prognosis in stage II (T1N1M0) breast cancer. Ann Surg. 1981 Nov;194(5):576–584. [PubMed]
  • Rosen PP, Lesser ML, Kinne DW. Breast carcinoma at the extremes of age: a comparison of patients younger than 35 years and older than 75 years. J Surg Oncol. 1985 Feb;28(2):90–96. [PubMed]
  • Schaefer G, Rosen PP, Lesser ML, Kinne DW, Beattie EJ., Jr Breast carcinoma in elderly women: pathology, prognosis, and survival. Pathol Annu. 1984;19(Pt 1):195–219. [PubMed]
  • Stalsberg H, Thomas DB. Age distribution of histologic types of breast carcinoma. Int J Cancer. 1993 Apr 22;54(1):1–7. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK