PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
 
Br J Cancer. 1997; 75(2): 178–179.
PMCID: PMC2063286

Mutations at codon 974 of the DPYD gene are a rare event.

Abstract

A mutation at codon 974 of the dihydropyrimidine dehydrogenase (DPD) gene was previously described in a cancer patient with undetectable DPD enzyme activity who experienced severe toxicity when treated with 5-fluorouracil. We have studied the frequency of this mutation in 29 Scottish subjects with low DPD enzyme activity and in 274 American subjects. We detected no mutations in the 606 alleles studied and conclude that mutations at codon 974 are a rare event.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (437K), or click on a page image below to browse page by page.
 
 

Images in this article

Click on the image to see a larger version.

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK