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Br J Cancer. 1998 October; 78(7): 966–970.
PMCID: PMC2063120

Risk of cancer other than Kaposi's sarcoma and non-Hodgkin's lymphoma in persons with AIDS in Italy. Cancer and AIDS Registry Linkage Study.


Record linkage was carried out between the national Registry of AIDS and 13 Cancer Registries (CRs) covering, in 1991, about 15% of the Italian population. Observed and expected numbers of cancers and standardized incidence ratios (SIRs) were assessed in 6067 persons with AIDS, for a total of 25,759 person-years. Significantly increased SIRs were found for Hodgkin's disease [8.9, 95% confidence interval (CI) 4.4-16.0], in which seven of 11 cases were of mixed cellularity type; invasive carcinoma of the cervix uteri (15.5; 95% CI 4.0-40.1); and non-melanomatous skin cancer (3.0, 95% CI 1.3-5.9), in which five of eight cases were basal cell carcinoma. An excess was also seen for brain tumours, but this may be partly due to misdiagnosis of brain non-Hodgkin's lymphoma or other brain diseases occurring near the time of the AIDS diagnosis. The risk for all cancer types, after exclusion of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), was approximately twice the general population risk. An increased SIR for Hodgkin's disease in persons with AIDS is thus confirmed, though it is many times smaller than that for NHL. An association with invasive carcinoma of the cervix is also shown at a population level. The excess of non-melanomatous skin cancer seems to be lower than in transplant recipients.

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  • Andrieu JM, Roithmann S, Tourani JM, Levy R, Desablens B, le Maignan C, Gastaut JA, Brice P, Raphael M, Taillan B. Hodgkin's disease during HIV1 infection: the French registry experience. French Registry of HIV-associated Tumors. Ann Oncol. 1993 Sep;4(8):635–641. [PubMed]
  • Franceschi S, Dal Maso L, Arniani S, Lo Re A, Barchielli A, Milandri C, Simonato L, Vercelli M, Zanetti R, Rezza G. Linkage of AIDS and cancer registries in Italy. Int J Cancer. 1998 Mar 16;75(6):831–834. [PubMed]
  • Lyter DW, Bryant J, Thackeray R, Rinaldo CR, Kingsley LA. Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men. J Clin Oncol. 1995 Oct;13(10):2540–2546. [PubMed]
  • Melbye M, Coté TR, Kessler L, Gail M, Biggar RJ. High incidence of anal cancer among AIDS patients. The AIDS/Cancer Working Group. Lancet. 1994 Mar 12;343(8898):636–639. [PubMed]
  • Reynolds P, Saunders LD, Layefsky ME, Lemp GF. The spectrum of acquired immunodeficiency syndrome (AIDS)-associated malignancies in San Francisco, 1980-1987. Am J Epidemiol. 1993 Jan 1;137(1):19–30. [PubMed]
  • Serraino D, Carbone A, Franceschi S, Tirelli U. Increased frequency of lymphocyte depletion and mixed cellularity subtypes of Hodgkin's disease in HIV-infected patients. Italian Cooperative Group on AIDS and Tumours. Eur J Cancer. 1993;29A(14):1948–1950. [PubMed]
  • Serraino D, Pezzotti P, Dorrucci M, Alliegro MB, Sinicco A, Rezza G. Cancer incidence in a cohort of human immunodeficiency virus seroconverters. HIV Italian Seroconversion Study Group. Cancer. 1997 Mar 1;79(5):1004–1008. [PubMed]
  • Sitas F, Bezwoda WR, Levin V, Ruff P, Kew MC, Hale MJ, Carrara H, Beral V, Fleming G, Odes R, et al. Association between human immunodeficiency virus type 1 infection and cancer in the black population of Johannesburg and Soweto, South Africa. Br J Cancer. 1997;75(11):1704–1707. [PMC free article] [PubMed]
  • Sun XW, Kuhn L, Ellerbrock TV, Chiasson MA, Bush TJ, Wright TC., Jr Human papillomavirus infection in women infected with the human immunodeficiency virus. N Engl J Med. 1997 Nov 6;337(19):1343–1349. [PubMed]
  • Tirelli U, Errante D, Dolcetti R, Gloghini A, Serraino D, Vaccher E, Franceschi S, Boiocchi M, Carbone A. Hodgkin's disease and human immunodeficiency virus infection: clinicopathologic and virologic features of 114 patients from the Italian Cooperative Group on AIDS and Tumors. J Clin Oncol. 1995 Jul;13(7):1758–1767. [PubMed]

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