Br J Cancer. 1998 September; 78(5): 561–565. | PMCID: PMC2063058 |
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
G. M. Taylor, S. Dearden, N. Payne, M. Ayres, D. A. Gokhale, J. M. Birch, V. Blair, R. F. Stevens, A. M. Will, and O. B. Eden
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
Abstract
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
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